See if 5-HTP helps with ADHD traits and eye movements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–65 with ADHD-related traits will complete screening questionnaires and, if eligible, a in-person session at the University of Sheffield. Participants will receive either 200 mg or 300 mg of 5-HTP or a placebo, then perform cognitive tasks while eye movements are recorded, followed by a 90-minute waiting period and a second task run. The aim is to explore whether 5-HTP can influence attention and eye-movement patterns that are linked to distractibility. This is an early, pilot-type investigation using a short-term administration of a nutritional supplement. The study is exploratory and focused on initial signals of efficacy and safety in this context.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-65 years of age
* Normal or corrected to normal vision with contact lenses.
* Score of \<9 or \>14 on the ASRS v5 (assessed in pre screen questionnaire)

Exclusion Criteria:

* Current use of psychostimulant medication or medication for the treatment of ADHD
* Current use of medications known to impact the serotonergic system (e.g., SSRIs).
* Smoking or vaping
* Pregnancy
* Breast feeding
* Lactose intolerance
* Veganism
* Dyslexia

Where it's running

• University of Sheffield
  Sheffield, South Yorkshire, United Kingdom Recruiting

Study contacts

• Study coordinator: Eleanor F Jackson
• Email: efjackson1@sheffield.ac.uk
• Phone: +447908873415

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Is a steam mask better than warm compresses for kids with a chalazion?

  A steam mask is tested to see if it helps pediatric chalazia more than traditional warm compresses.

  Recruiting University of Sheffield · Sheffield · NCT07721779

• Telehealth in MND: TiM online platform for people with MND

  This project lets people with MND in the UK use an online telehealth platform to learn about and sign up for MND studies and share health information from home.

  Recruiting University of Sheffield · Sheffield · NCT07132879

• Low sex‑hormone levels in genetic neurodevelopmental conditions

  This project will test whether people with certain genetic neurodevelopmental conditions have low sex hormones (hypogonadism) and how common it is.

  Recruiting University of Sheffield · Sheffield, Select · NCT07049042

• Comparing CAT-guided self-help and CBT-guided self-help for people returning to NHS talking therapy

  This project will try CAT-guided self-help and compare it with CBT-guided self-help for people with anxiety or low mood who are returning to NHS Talking Therapies.

  Recruiting at 2 sites University of Sheffield · Ashton-under-Lyne and 1 other locations · NCT06806176

• Identifying pathogens in febrile patients using gene expression

  This study is trying to find out if looking at gene responses in feverish patients can help doctors quickly tell if they have enteric fever or another infection, especially in places with limited resources.

  Recruiting University of Sheffield · Vellore · NCT04878549

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.