Secondary Care Pathway Review for Colorectal Cancer
Official title: A Retrospective Review of the Secondary-care Colorectal Cancer Pathway Within NHS Lothian: An Evaluation of 3 Years of Pathway Performance
Run by University of Edinburgh · NCT07430527 · Data updated 2026-11-12
This study looks at how the colorectal cancer pathway in secondary care is working, using routinely collected data to see how quickly people are diagnosed and treated after a positive FIT test.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25000 (estimated) |
| Sponsor | University of Edinburgh Academic / other |
| Locations | 2 sites (Edinburgh and 1 other locations) |
| Status | Recruiting |
| Started | May 6, 2026 |
| Main results expected | August 31, 2027 |
| Study ends | August 31, 2030 |
| Registry record updated | August 28, 2026 |
| Trial ID | NCT07430527 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults managed within the NHS Lothian CRC USoC/urgent pathway with red-flag symptoms from April 2022 to August 2025.
✕Probably not a fit
Patients not along the NHS Lothian urgent pathway or those diagnosed after August 2025 may not be directly impacted by the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective observational analysis of patients managed through NHS Lothian's urgent suspicion of cancer pathway for colorectal cancer from April 2022 to August 2025, with a 5-year follow-up through August 2030. It uses electronic health records to examine patient characteristics, investigations, cancer outcomes, and mortality, linking multiple datasets. The study aims to identify associations that predict significant bowel pathology and to map patient journeys and service performance via key indicators such as time to diagnosis and treatment. Statistical methods will include multivariate logistic regression to enrich for colorectal cancer and significant pathology using routinely available data. The work will inform potential improvements in the USoC pathway and resource use in high-demand colorectal services.
Why it matters
Potential benefit: If successful, the findings could help streamline referral pathways and reduce delays in diagnosis and treatment for colorectal cancer.
How similar studies have gone: Previous work in similar pathways has shown that retrospective analyses can illuminate bottlenecks and improve referral timing, though this exact dataset and setting are novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients managed within the NHS Lothian CRC USoC/urgent pathway (including urgent referrals) due to 'red-flag' symptoms concerning of CRC from April 2022 to August 2025. Exclusion Criteria: * Under the age of 18. * History of inflammatory bowel disease. * Under polyp surveillance. * Previous diagnosis of CRC.
Where it's running
-
NHS Lothian
Edinburgh, United Kingdom Recruiting -
NHS Lothian
Edinburgh, United Kingdom Not yet recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.