Screening for colorectal cancer using polygene methylation detection in a community population

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to evaluate the effectiveness of polygene methylation detection for colorectal cancer screening among 80,000 permanent residents in Yangzhou. Participants will complete a colorectal cancer risk assessment questionnaire and undergo polygene methylation testing, with those testing positive referred for further validation through colonoscopy. The study will track outcomes over five years, assessing the sensitivity, specificity, and detection rates of precancerous lesions. The goal is to establish real-world effectiveness of this screening method in a large community setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\) Permanent resident population of Yangzhou; 2) Chronological age: 40\~74 years, including critical value (refer to birth date of id card); 3) Have full capacity of conduct; 4) After enrollment, they could voluntarily cooperate to complete the Colorectal cancer Risk Factor Assessment Questionnaire and accept telephone follow-up; 5) Agree to timely feed back the information related to tumor diagnosis to the investigator during the study process; 6) Willing and able to sign informed consent.

Exclusion Criteria:

* 1\) History of colorectal cancer and other malignant tumors; 2) previous colorectal resection; 3) are receiving any cancer-related treatment; 4) Those who have received major surgical treatment such as blood transfusion and transplantation within 3 months; 5) Participate in other interventional clinical investigators within 3 months; 6) Pregnant or lactating women; 7) Patients with autoimmune diseases, genetic diseases, mental diseases/disabilities and other diseases considered unsuitable for the study by the researcher; 8) Poor compliance, unable to complete the study according to the judgment of the researcher.

Where it's running

• Northern Jiangsu People's Hospital
  Yangzhou, Jiangsu, China Recruiting
• Yangzhou First People's Hospital
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Liu Rui, Doctor — Singlera Genomics Inc.
• Study coordinator: Liu Jun, Master
• Email: sbyy_liujun@163.com
• Phone: 18051061318

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.