Safety and effectiveness of NOA LIFT vs VOLIFT for correcting nasolabial folds in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this Phase 3 trial, adults with moderate to severe nasolabial folds are randomized to receive either NOA LIFT or JUVÉDERM VOLIFT with lidocaine. The study compares safety and effectiveness over about 12 months after treatment. Participants receive deep dermal injections at multiple sites in China and are followed to monitor adverse events and treatment outcomes. Approximately 288 participants will be enrolled across three Beijing/Guangzhou/Shenzhen centers. The trial uses a 2:1 randomization in favor of NOA LIFT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Moderate (2) or Severe (3) on the 5-point Nasolabial Fold Severity Scale (NLFSS) for each nasolabial fold (NLF) on evaluator live assessment (both sides must qualify and have the same score)

Exclusion Criteria:

* Current cutaneous or mucosal inflammatory or infectious processes, abscess, unhealed wound, or cancerous or precancerous lesion in the treatment area(s).
* Current enrollment in an investigational drug or device study or participation in such a study within 30 days before enrollment.

Where it's running

• Peking Union Medical College Hospital (West) - Xidan Campus /ID# 267457
  Beijing, Beijing Municipality, China Recruiting
• Zhujiang Hospital /ID# 276566
  Guangzhou, Guangdong, China Recruiting
• Peking University Shenzhen Hospital /ID# 268255
  Shenzhen, Guangdong, China Recruiting
• Nanjing Drum Tower Hospital /ID# 267555
  Nanjing, Jiangsu, China Recruiting
• Zhongda Hospital Of Southeast University /ID# 276571
  Nanjing, Jiangsu, China Recruiting
• Xianyang Hospital of Yanan University /ID# 267936
  Xianyang, Shaanxi, China Recruiting

Study contacts

• Study coordinator: Abbvie Call Center
• Email: abbvieclinicaltrials@abbvie.com
• Phone: 844-663-3742

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.