RADIESSE Injectable Implant for correcting moderate to severe nasolabial folds

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the long-term safety and effectiveness of the RADIESSE Injectable Implant for filling moderate to severe nasolabial folds in Chinese adults. Participants receive treatment in both sides of the face and may get an optional touch-up at one month, with follow-up through 24 months after the last treatment. The study monitors safety, degradation profile, and aesthetic results using standard facial grading scales. Eligibility requires defined wrinkle severity and a commitment to avoid other facial treatments in the NLF area during participation. Exclusion criteria rule out prior identifiable filler material in the area, active infection, recent fillers, and recent facial procedures that could affect assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* WSRS score of 3 (moderate) or 4 (severe) in both right and left NLFs, as determined live by the treating investigator. The WSRS score for the right and the left NLF does not have to be equal.
* Willing to abstain from other aesthetic treatments in the NLF area during study participation.

Exclusion Criteria:

* Prior dermal filler or implant material detectable in the NLF area by ultrasound.
* Active infection or acute inflammation at treatment sites.
* Hyaluronic Acid or collagen filler treatment in NLFs within 12 months.
* CaHA or Poly L-Lactic Acid filler treatment in NLFs within 24 months.
* Recent facial dermal therapies in the midface region within the past 6 months.
* Prior facial surgery or implants that could interfere with assessments.

Where it's running

• Merz Investigative Site
  Beijing, China Recruiting
• Merz Investigative Site
  Changde, China Recruiting
• Merz Investigative Site
  Chengdu, China Recruiting
• Merz Investigative Site
  Gaozhou, China Recruiting
• Merz Investigative Site
  Hangzhou, China Recruiting
• Merz Investigative Site
  Nanjing, China Recruiting

Study contacts

• Study coordinator: Public Disclosure Manager
• Email: Aesthetic.Trials@merz.com
• Phone: +1 984-301-3095

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• DMFI150 to reduce nasolabial fold wrinkles

  This trial will test a single treatment of DMFI150 to see if it reduces moderate-to-severe nasolabial fold wrinkles in adults aged 18–70.

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• Bridging Technique with AILEENE Vol. 2 for Softening Nasolabial Folds

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.