Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized, open-label study compares three groups of adults with sepsis admitted to the ICU: standard care alone, standard care plus vitamin C, and standard care plus Ruta C. The primary aim is to see if these adjunctive therapies reduce ICU length of stay and improve outcomes such as 28-day mortality, organ dysfunction, septic shock incidence, and need for mechanical ventilation or vasopressors. It also looks at changes in inflammatory and oxidative stress markers like IL-6, CRP, MDA, and white blood cell count. Patients must be 21 years or older, meet Sepsis-3 criteria, and be able to take oral tablets, with several exclusions for comorbidities and current therapies. Conducted at Ain Shams University in Cairo, the study randomizes participants to assess potential added benefits of Ruta C over vitamin C alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1-Adult patients aged ≥21 years. 2- Confirmed diagnosis of sepsis based on Sepsis-3 criteria. 3- ICU admission within 24 hours of enrollment. 4-Patients able to swallow oral tablets.

Exclusion Criteria:

* 1- Patients with active chronic inflammatory or autoimmune diseases. 2- End-stage liver disease or advanced cancer. 3- Initial SOFA score ≥15. 4- Pregnant or breastfeeding women. 5- Patients who are nothing per oral (NPO). 6- Known allergy or hypersensitivity to rutin or vitamin C. 7- Patients already receiving antioxidant therapy before enrollment. 8- Participation in another clinical trial during the last 30 days. 9- Presenting with septic shock at enrollment.

Where it's running

• Al-Demerdash Hospital, Ain Shams University
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Study coordinator: hebaallah adel soliman, BPharm
• Email: heba.allah.adel@pharma.asu.edu.eg
• Phone: 00201121934293

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.