Royal jelly and propolis for hypertension: does it lower inflammation and oxidative stress?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional, double-blind randomized trial will compare royal jelly plus propolis versus placebo over two months in adults with stage 1–2 hypertension. The study focuses on inflammatory and oxidative stress markers to see if the supplements offer additional benefits beyond standard hypertension care. Eligible participants have had stable antihypertensive treatment for at least six months and no recent medication changes. The research is conducted at Denise Mafra in Niterói, Brazil, led by Universidade Federal Fluminense. Safety and adherence will be monitored throughout the trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of stage 1 and 2 hypertension
* Regular treatment for more than 6 months
* There have been no changes in medication doses over the last three months.

Exclusion Criteria:

* Autoimmune and infectious diseases, diabetes
* Chronic kidney disease, liver disease, cancer and AIDS
* Pregnant women
* Use of catabolic drugs or antibiotics
* Use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotic
* Habitual intake of royal jelly and propolis

Where it's running

• Denise Mafra
  Niterói, Rio de Janeiro, Brazil Recruiting

Study contacts

• Study coordinator: Denise Mafra, PhD
• Email: dmafra30@gmail.com
• Phone: +5521985683003

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.