How surgical approach affects posture-breathing coordination after lobectomy
Official title: Impact of Surgical Approach on Adaptation of Posture-respiratory Coupling
Run by Assistance Publique - Hôpitaux de Paris · NCT06276530 · Data updated 2026-11-12
This study will see if minimally invasive lobectomy (robotic or video-assisted) versus traditional thoracotomy changes how posture and breathing coordinate in people having surgery for resectable non-small cell lung cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | March 25, 2024 |
| Main results expected | March 2026 |
| Study ends | April 2026 |
| Registry record updated | September 2, 2025 |
| Trial ID | NCT06276530 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with resectable non-small cell lung carcinoma admitted for lobectomy who will undergo either conventional posterolateral thoracotomy or minimally invasive (robotic or video-assisted) lobectomy are ideal candidates.
✕Probably not a fit
Patients requiring extended lung resections, those with unresectable disease, or people unable to attend the in-person imaging and motion testing are unlikely to benefit from or be eligible for this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center interventional study enrolls patients with resectable non-small cell lung cancer scheduled for lobectomy and compares conventional posterolateral thoracotomy with minimally invasive approaches (VATS/RATS). Investigators will perform EOS musculoskeletal imaging, optoelectronic movement capture, and stabilometric force-platform measurements before and after surgery to quantify posture, alignment, balance, and breathing-related movements. The protocol aims to link objective postural and respiratory adaptations to differences in postoperative pain, complications, and quality of life seen with minimally invasive techniques. By identifying physiopathologic mechanisms, the work seeks to explain why VATS/RATS often lead to faster recovery than open thoracotomy.
Why it matters
Potential benefit: If successful, the findings could help guide surgical choice and rehabilitation to reduce postoperative pain and speed recovery of breathing and posture after lobectomy, improving patients' quality of life.
How similar studies have gone: Prior studies have shown minimally invasive lobectomy reduces postoperative pain and complications compared with thoracotomy, but applying detailed posture-respiratory coupling measurements to explain that benefit is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients admitted for major lung resection * Surgical approach by conventional postern-lateral thoracotomy * Surgical approach by minimally invasive RATS Exclusion Criteria: \- Extended lung resection
Where it's running
-
Department of Thoracic and Vascular Surgery Tenon University Hospital
Paris, France Recruiting
Study contacts
- Principal investigator: Harry ETIENNE, M.D., PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Harry ETIENNE, M.D., PhD Degree
- Email: harry.etienne@aphp.fr
- Phone: 06.67.96.82.89
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Adaptive Chemotherapy for PD-L1 High Resectable NSCLC: A Chemo-PHREE Trial
This study tests cemiplimab in adults with resectable non-small cell lung cancer to see if surgery can be pursued without preceding chemotherapy for some patients.
-
Resiliency and Operative Success for Lung Cancer Surgery: Prehab with In-Person and BeFitMe Options
This trial tests two prehab programs—one in-person and one virtual—to see if pre- and post-surgery physical therapy and relaxation help adults undergoing lung cancer surgery feel steadier and have better recovery.
-
Combining adebrelimab with chemotherapy for lung cancer treatment
This study is testing if adding adebrelimab to chemotherapy helps patients with early-stage lung cancer feel better and have better treatment outcomes before surgery.
-
Treatment for lung cancer patients who had surgery but are not disease-free
This study is testing two new immunotherapy treatments for lung cancer patients who have had surgery but still have some disease to see if they can help them stay cancer-free longer.
-
Predicting how tumors respond to immune therapies using a live diagnostic platform
This study is testing a new way to predict how well immune therapies will work for patients with different types of solid tumors, including early-stage and metastatic cancers.
-
Combining camrelizumab with chemotherapy for lung cancer treatment
This study is testing if combining a new drug called camrelizumab with chemotherapy can help people with certain types of lung cancer before surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.