Research on factors affecting bronchiectasis progression
Research on the Mechanism Affecting Progression of Bronchiectasis Based on Omics Method
This study looks at how different factors, like bacteria in the lungs, affect the worsening of bronchiectasis in people with this chronic lung condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Academic / other |
| Locations | 3 sites (Guiyang, Guizhou and 2 other locations) |
| Trial ID | NCT05731427 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the mechanisms influencing the progression of bronchiectasis, a chronic respiratory condition characterized by irreversible bronchial dilation. It aims to analyze the relationship between airway microbiota, particularly Pseudomonas aeruginosa colonization, and disease severity. The study will collect demographic data, lung function tests, and biological samples, including sputum, stool, and peripheral blood, to assess inflammatory markers and microbiota composition. The findings may help in understanding the heterogeneity of bronchiectasis and its clinical implications.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years or older with a confirmed diagnosis of bronchiectasis and chronic expectoration.
Not a fit: Patients with traction bronchiectasis or those lacking essential clinical information may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for patients with bronchiectasis, potentially enhancing their quality of life.
How similar studies have performed: Previous studies have indicated significant relationships between airway microbiome and bronchiectasis severity, suggesting that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * 18 years or older * Bronchiectasis confirmed by high-resolution computed tomographic scan(HRCT) * Chronic expectoration with ability to provide a sputum sample at the study visit * Provision of written informed consent Exclusion criteria: * Traction bronchiectasis * Lack of important clinical information
Where this trial is running
Guiyang, Guizhou and 2 other locations
- Guizhou Provincial people's Hospital — Guiyang, Guizhou, China (Recruiting)
- Wuhan Union Hospital — Wuhan, Hubei, China (Recruiting)
- Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital — Yichang, Hubei, China (Recruiting)
Study contacts
- Principal investigator: Xiaorong Wang — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Study coordinator: Xiaorong Wang
- Email: rong-100@163.com
- Phone: 18627195231
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.