Renal Health in Adults with Inflammatory Bowel Disease and the General Population

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter prospective observational study compares the prevalence of renal dysfunction and kidney-related complications between adults with IBD (Crohn’s disease or ulcerative colitis) and matched controls from the general population. Participants undergo routine labs, urinalysis with albumin-to-creatinine ratio, and kidney/urinary tract ultrasound, with IBD activity measured by standard indices. The study aims to describe how often kidney issues occur in IBD and how they relate to disease activity, potential medications, and other risk factors. Enrollment targets roughly 6,000 participants, including 3,000 with IBD and 3,000 without IBD, across several Polish centers. Results could inform screening and management of renal health in IBD patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years
* Confirmed IBD based on the overall clinical picture and endoscopic examination, or no IBD (control group without IBD)
* Consent to participate in the study
* Cognitive abilities sufficient to complete the questionnaires

Exclusion Criteria:

* diabetes
* dysuric symptoms suggestive of urinary tract infections
* in women, menstruation (urinalysis can be performed 3 days before the onset and 3 days after the end of menstruation)
* refusal to participate in all procedures performed in the study
* age under 18 or over 80
* pregnancy
* other serious comorbidities whose presence or exacerbation may cause abnormalities in laboratory tests suggesting kidney disease
* previous surgery whose presence may cause abnormalities in laboratory tests suggesting kidney disease
* extreme physical exertion within 7 days before the test (marathons, half-marathons, triathlons) and intense physical exertion - strength training - within 1 day before the test. \[moderate physical exertion such as walking, swimming, or cycling is not a contraindication\]. • Excessive alcohol consumption 14 days before the study
* Inability to perform necessary tests: e.g., inability to perform an imaging test
* Unavailability of data: if the study is based on registry data, exclusion of individuals for whom there is incomplete data
* Dehydration
* Use of nephrotoxic medications\* within a month before and during the study
* Use of angiotensin inhibitors, sartans, or flozins that were introduced into treatment within \<3 months

  \*Nephrotoxic drugs:
* Nonsteroidal anti-inflammatory drugs (NSAIDs) - occasional use is not contraindicated, but use for ≥ 10 days is an exclusion criterion
* Gold salts
* Penicillamine
* Interferon alpha
* Antituberculosis drugs (rifampicin, ethambutol, isoniazid)
* Pamidronate
* Biseptol
* Antiviral drugs (acyclovir)
* Anticonvulsants (carbamazepine, diazepam, phenobarbital)
* Cyclosporine A, tacrolimus
* Chinese herbs
* Oncology drugs (cisplatin)

Where it's running

• National Medical Institute of the Ministry of the Interior and Administration, Clinic of Gastroenterology and Internal Diseases
  Warsaw, Warszawa, Poland Recruiting

Study contacts

• Study coordinator: Krzysztof Jaroń, MD, MPharm
• Email: krzysztof.jaron@pimmswia.gov.pl
• Phone: +48 477 22 12 40

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Observational look at how Kremezin works in adults with advanced chronic kidney disease

  This study tests whether Kremezin helps adults with advanced kidney disease when used as part of routine care, by tracking safety and kidney function over up to 48 weeks.

  Recruiting HK inno.N Corporation · Seoul · NCT07930169

• Kidney and Heart Health in Adults with Type 2 Diabetes and CKD Treated with Semaglutide in China

  This study tests whether semaglutide injections help kidney and heart health in adults with type 2 diabetes and chronic kidney disease.

  Recruiting Phase 4 Novo Nordisk A/S · Fuyang, Anhui and 25 other locations · NCT07900438

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• Optimised Cardio-Renal Care for CKD and heart disease

  This study tests whether a specialised Cardio-Renal Clinic can improve heart and kidney health and quality of life for adults with chronic kidney disease and cardiovascular disease.

  Recruiting Odense University Hospital · Svendborg · NCT07835828

• NMR-based Risk Test and Digital Health Support for midlife adults in Eloisa

  This study tests whether an NMR metabolomics risk test can guide tailored digital health programs for midlife adults at risk of diabetes, heart disease, stroke, kidney disease, or fatty liver.

  Recruiting University of Eastern Finland · Savonlinna · NCT07820800

• Arterial stiffness in children and young people with CKD and hypertension

  This study will test whether arterial stiffness is higher in children and young people with chronic kidney disease and high blood pressure compared with their peers, using a one-time assessment and follow-up for those with high BP.

  Recruiting King's College London · London, Greater London · NCT07768865

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.