Remote monitoring platform for Frontotemporal Lobar Degeneration syndromes
A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes
This study is testing a new remote monitoring system using wearable sensors to see how well it can track movement and thinking changes in people with Progressive Supranuclear Palsy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 40 Years to 89 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 2 sites (Baltimore, Maryland and 1 other locations) |
| Trial ID | NCT05956834 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enroll approximately 60 patients diagnosed with Progressive Supranuclear Palsy (PSP) over 24 months and follow them for 12 months. The primary goal is to develop a multi-modal remote monitoring platform that utilizes wearable sensors and mobile health technology to assess motor symptoms and cognitive functions in patients with FTLD syndromes. The study will take place at two leading medical centers, Johns Hopkins Hospital and Massachusetts General Hospital, focusing on collecting longitudinal data to validate the monitoring solution.
Who should consider this trial
Good fit: Ideal candidates are adults with a clinical diagnosis of possible or probable PSP who can walk unassisted and have a caregiver to assist with study procedures.
Not a fit: Patients with frequent falls or those requiring a walker for ambulation, as well as those with other neurological or psychiatric conditions that hinder participation, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management and monitoring of motor and cognitive symptoms in patients with FTLD syndromes.
How similar studies have performed: Other studies have shown promise in using remote monitoring technologies for similar conditions, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of possible or probable PSP as defined by the 2017 MDS criteria * Fluent in reading and speaking English and capable of providing informed consent based on the principal investigator's judgement * Able to walk 10 feet unassisted at the time of initial enrollment * Must have a caregiver or study partner who is willing and able to assist with all study-related procedures Exclusion Criteria: * Any neurological, medical, or psychiatric condition that would preclude participation in study activities based on the investigator's judgment. * A history of frequent falls defined as more than 5 falls per month, or who require a walker to ambulate safely at baseline will not be eligible to participate in the study.
Where this trial is running
Baltimore, Maryland and 1 other locations
- Johns Hopkins School of Medicine — Baltimore, Maryland, United States (Recruiting)
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Study coordinator: Mansi Sharma, BS
- Email: msharma13@mgh.harvard.edu
- Phone: 6176432400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.