Relation of single- and dual-task obstacle walking with fatigue and disability in relapsing MS
Official title: Relationship Between Single- and Dual-Task Obstacle Crossing Performance and Fatigue and Disability Levels in Patients With Relapsing-Remitting Multiple Sclerosis
Run by Afyonkarahisar Health Sciences University · NCT07736482 · Data updated 2026-11-12
We test whether performing a cognitive task while walking and while crossing obstacles is linked to fatigue and disability in people with relapsing–remitting MS.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Afyonkarahisar Health Sciences University Academic / other |
| Locations | 1 site (Afyonkarahisar, Merkez) |
| Status | Recruiting |
| Started | March 20, 2026 |
| Main results expected | July 25, 2026 |
| Study ends | February 20, 2027 |
| Registry record updated | July 31, 2026 |
| Trial ID | NCT07736482 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–65 with Relapsing-Remitting MS, relapsing‑remitting course, EDSS 0–6, MoCA ≥26, Turkish speaking, stable disease in the last 6 months.
✕Probably not a fit
Patients with progressive MS, significant cognitive impairment (MoCA <26), or unstable disease may not experience the same insights or benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross‑sectional observational study will examine how obstacle crossing performance changes when a concurrent cognitive task is added, compared with single-task walking, in adults with relapsing‑remitting MS. Participants will complete four walking conditions (single-task and dual-task walking; single-task and dual-task obstacle crossing) and a cognitive task (serial subtraction) while walking. Clinical measures of fatigue, walking limitation, cognition, quality of life, and fear of movement will be collected to explore associations with obstacle-crossing performance. The goal is to determine whether more demanding gait tasks reveal mobility and fatigue relationships that are not evident in standard walking tests. The study is conducted at Afyonkarahisar Health Sciences University and targets adults aged 18–65 with Relapsing-Remitting MS.
Why it matters
Potential benefit: If successful, results could help clinicians understand and screen for mobility limitations that emerge under real-life multitasking.
How similar studies have gone: Prior work has explored dual-task walking in MS, but this study adds obstacle-crossing under dual-task conditions to further clarify its relationship with fatigue and disability.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years. * Diagnosis of Multiple Sclerosis according to the 2017 McDonald criteria. * Diagnosis of Relapsing-Remitting Multiple Sclerosis. * Expanded Disability Status Scale (EDSS) score between 0 and 6. * Clinically stable disease during the previous 6 months. * Montreal Cognitive Assessment (MoCA) score of 26 or higher. * Able to speak and understand Turkish. * Able to provide written informed consent. Exclusion Criteria: * Multiple sclerosis relapse within the previous month. * Physician-diagnosed psychiatric disorder. * Neurological, orthopedic, cardiac, or pulmonary disease other than Multiple Sclerosis that could interfere with study assessments. * Montreal Cognitive Assessment (MoCA) score below 26.
Where it's running
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Afyonkarahisar Health Sciences University
Afyonkarahisar, Merkez, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Yunus Emre Kundakcı, Assoc. Prof.
- Email: y.emre.kndkc@gmail.com
- Phone: +90 272 246 28 34|
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.