Rehabilitation and education for airway clearance in patients with NTM-PD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effects of pulmonary rehabilitation and airway clearance education in adults diagnosed with nontuberculous mycobacterial pulmonary disease (NTM-PD). Participants will undergo an 8-week program consisting of biweekly sessions focused on improving lung function, symptom relief, and quality of life. The study will assess outcomes through various evaluations, including pulmonary function tests, symptom assessments, and quality of life surveys, at multiple time points throughout the intervention and follow-up. The goal is to determine if this non-pharmacological approach can enhance sputum culture conversion rates and overall patient well-being.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 20 years or older at the time of enrollment.
* Diagnosis of nontuberculous mycobacterial pulmonary disease (NTM-PD) according to the 2020 American Thoracic Society (ATS) guidelines.
* Identification of clinically significant NTM species, including:

Mycobacterium avium / Mycobacterium intracellulare / Mycobacterium abscessus / Mycobacterium massiliense / Mycobacterium kansasii /

* Able to undergo pulmonary rehabilitation and airway clearance training as part of the study protocol.
* Willing to provide written informed consent to participate in the study.

Exclusion Criteria:

* Currently pregnant or actively breastfeeding.
* Unable to participate in pulmonary rehabilitation due to severe mobility impairment or neuromuscular disorders.
* History of massive hemoptysis or other medical conditions where airway clearance techniques may be contraindicated.

Where it's running

• Seoul National University Bundang Hospital
  Seongnam-si, Gyeonggi-do, South Korea Recruiting
• Taipei Veterans General Hospital
  Taipei, Beitou Dist, Taiwan Recruiting

Study contacts

• Study coordinator: Hyung-Jun Kim, MD
• Email: dr.hjkim@snu.ac.kr
• Phone: +82-31-787-7844

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exercise program for patients with nontuberculous mycobacterial pulmonary disease

  This study is testing if a special exercise program can help people aged 40-80 with nontuberculous mycobacterial pulmonary disease breathe better and feel healthier.

  Recruiting Yonsei University · Seoul · NCT06488495

• Investigation of Nontuberculous Mycobacteria Outbreaks in Healthcare Settings

  This study is trying to find out if nontuberculous mycobacteria infections in healthcare settings are spreading between patients and where they might be coming from.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06155747

• Hypertonic saline inhalation for NTM lung disease

  This trial tests whether starting inhaled 3% hypertonic saline early helps people with non-tuberculous mycobacterial lung disease feel better and clear bacteria better, compared with starting with normal saline first.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07647575

• Biomarkers linked to response to phage treatment for nontuberculous mycobacterial and other infections

  This project will test whether blood and airway biomarkers can show which adults with refractory nontuberculous mycobacterial or other bacterial infections respond to bacteriophage treatment.

  Recruiting NYU Langone Health · New York, New York · NCT07076238

• Biomarker test using soluble PD-1 to predict progression in nodular-bronchiectatic NTM lung disease

  This study tests whether levels of soluble PD-1 in blood can predict how quickly nodular-bronchiectatic NTM lung disease will progress.

  Recruiting National Taiwan University Hospital · Taipei · NCT05678166

• Using Hypertonic Saline Inhalation to Treat Mycobacterium Avium Complex Lung Disease

  This study tests if inhaling Hypertonic Saline along with regular care can help people with Mycobacterium avium complex lung disease feel better and improve their quality of life.

  Recruiting Phase 4 Radboud University Medical Center · Nijmegen · NCT05192057

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.