Registry to optimize management and outcomes for patients with acute myocardial infarction
Official title: OPTIMISER Registry - A Prospective Cohort Study to Describe the OPTIMal Management and Outcomes of PatIents PreSEnting With Acute MyocaRdial Infarction
Run by Luzerner Kantonsspital · NCT04988672 · Data updated 2026-11-12
This study is looking at how well different treatments work for patients who have had a heart attack and received a specific procedure called PCI, to see what helps them recover better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 4000 (estimated) |
| Sponsor | Luzerner Kantonsspital Academic / other |
| Locations | 1 site (Lucerne) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2030 |
| Registry record updated | October 6, 2023 |
| Trial ID | NCT04988672 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals over 18 years old who are newly diagnosed with AMI or have been diagnosed within the last five years.
✕Probably not a fit
Patients who are unwilling or unable to provide informed consent or those with conditions unrelated to acute coronary syndrome will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The OPTIMISER Registry aims to collect both baseline and clinical data from patients presenting with acute myocardial infarction (AMI) who are treated with percutaneous coronary intervention (PCI). This observational study will analyze procedural success and clinical outcomes, comparing results across different clinical subgroups. It will assess various procedural outcomes, long-term clinical outcomes, and the impact of different devices and strategies used during PCI. Additionally, the study will evaluate predictors for stent implantation failure and the effects of antithrombotic regimens on patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies and outcomes for patients experiencing acute myocardial infarction.
How similar studies have gone: Other studies have shown success in optimizing treatment strategies for AMI, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject \>18 years of age * Individuals who are newly diagnosed with AMI or have been diagnosed with AMI (STEMI or NSTEMI) within the last 5 years (since 2016). * Subjects must be willing to sign a patient informed consent (PIC) OR a patient ́s relative/ proxy are willing to provide PIC or patients have signed the General Consent (GK). Exclusion Criteria: * Patient unwilling or unable to provide informed consent * Patients with no ACS/AMI (e.g. Takotsubo cardiomyopathy, acute heart failure not related to AMI)
Where it's running
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Luzerner Heart Centre
Lucerne, Switzerland Recruiting
Study contacts
- Principal investigator: Florim Cuculi, M.D. — Luzerner Kantonsspital
- Study coordinator: Florim Cuculi, M.D.
- Email: florim.cuculi@luks.ch
- Phone: +41412052134
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Breisgau PHENO-HEART MI: Understanding Heart Attack Biology in Adults
This observational study in adults with STEMI or NSTEMI looks at the body’s immune response after a heart attack to understand how tissue damage and healing affect outcomes.
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Early single antiplatelet therapy after IVUS-guided PCI in ACS
This study tests whether stopping aspirin early and continuing a potent P2Y12 inhibitor alone is safe and effective after IVUS-guided PCI in people with acute coronary syndrome.
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Surgery to treat myocardial bridge in coronary arteries
This study tests if a special heart surgery can help people with symptoms from a condition called myocardial bridge feel better and improve their quality of life.
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Using a smartphone device to record 12-lead ECGs for heart attack diagnosis
This study is testing a smartphone device that records heart activity to see if it can help doctors quickly diagnose heart attacks in adults who come to the emergency room with chest pain.
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Using Dapagliflozin to Prevent Heart Changes After a Heart Attack
This study tests if the medication dapagliflozin can help prevent heart problems in people who have had a heart attack and have some heart weakness.
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Registry collecting data on patients undergoing heart artery procedures
This study is collecting information from patients who are having heart artery procedures to see how they do during and after their treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.