Clinical trial Recruiting at 20 sites Observational Ages 18 to 45 Women only

Registry for pregnancy and fertility in young breast cancer patients

Official title: An Italian Multicenter Prospective Cohort Study on Fertility Preservation and Pregnancy Issues in Young Breast Cancer Patients: PREgnancy and FERtilty (PREFER)

Run by IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy · NCT02895165 · Data updated 2026-11-12

This study is trying to learn more about how young women with breast cancer can preserve their fertility and manage pregnancy-related issues.

More Pregnancy trials

Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment1000 (estimated)
SponsorIRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Academic / other
Drugs / interventionschemotherapy, radiation
Locations23 sites (Asti, Asti and 22 other locations)
StatusRecruiting
StartedNovember 2012
Main results expectedNovember 2027
Study endsNovember 2032
Registry record updatedApril 30, 2026
Trial IDNCT02895165 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include young women aged 18 to 45 with a breast cancer diagnosis who have not yet undergone radiation or chemotherapy.

Probably not a fit

Patients with stage IV breast cancer or those unable to provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PREgnancy and FERtility (PREFER) program is designed to enhance care and understanding of fertility preservation and pregnancy issues among young women diagnosed with breast cancer. It consists of two main components: PREFER-FERTILITY, which gathers data on fertility preservation preferences and outcomes, and PREFER-PREGNANCY, which focuses on pregnancy-related issues in this patient population. The initiative began at the National Institute for Cancer Research in Italy and has expanded to include multiple institutions under the Gruppo Italiano Mammella study group.

Why it matters

Potential benefit: If successful, this program could significantly improve fertility preservation options and pregnancy outcomes for young breast cancer patients.

How similar studies have gone: While the approach is comprehensive, similar studies have shown promise in addressing fertility and pregnancy issues in cancer patients, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* breast cancer diagnosis
* age between18 and 45 years (only for PREFER-FERTILITY)
* have not received any radiation or chemotherapy for cancer before enrolment (only for PREFER-FERTILITY)
* absence of metastatic disease (only for PREFER-FERTILITY)
* diagnosis of breast cancer during pregnancy or within 1 year from the end of pregnancy or pregnancy after prior diagnosis and treatment for breast cancer (only for PREFER-PREGNANCY)
* informed consent

Exclusion Criteria:

* inability to provide written informed consent
* stage IV disease at diagnosis (only for PREFER-FERTILITY)
* serious psychiatric disorders

Where it's running

  • Ospedale Cardinal Massaia
    Asti, Asti, Italy
    Recruiting
  • Presidio Ospedaliero 'Antonio Perrino'
    Brindisi, Br, Italy
    Recruiting
  • Azienda Ospedaliera S. Croce e Carle
    Cuneo, Cn, Italy
    Recruiting
  • Arcispedale S. Anna - A.O.U. di Ferrara
    Cona, Fe, Italy
    Recruiting
  • Irccs Aou San Martino - Ist
    Genoa, Ge, Italy
    Recruiting
  • Ospedale Vito Fazzi
    Lecce, Le, Italy
    Recruiting
Show 17 more locations
  • Ospedale Unico Versilia
    Lido di Camaiore, Lu, Italy
    Recruiting
  • Azienda Ospedaliera Carlo Poma
    Mantua, Mn, Italy
    Recruiting
  • AOU Pisana - Ospedale S. Chiara
    Pisa, Pisa, Italy
    Recruiting
  • Fondazione S. Maugeri IRCCS
    Pavia, Pv, Italy
    Recruiting
  • Azienda Ospedaliera S. Carlo
    Potenza, Pz, Italy
    Recruiting
  • Arcispedale Santa Maria Nuova di Reggio Emilia
    Reggio Emilia, Reggio Emilia, Italy
    Recruiting
  • Azienda Ospedaliera n. 1 - Annunziata
    Sassari, Ss, Italy
    Recruiting
  • Fondazione del Piemonte per l'Oncologia - IRCC di Candiolo
    Candiolo, To, Italy
    Recruiting
  • ASS1 Triestina
    Trieste, Trieste, Italy
    Recruiting
  • AOU SM Misericordia
    Udine, Ud, Italy
    Recruiting
  • Ospedale Sacro Cuore Don Calabria
    Negrar, Ve, Italy
    Recruiting
  • A.O.U. Federico II
    Naples, Italy
    Recruiting
  • Istituto Nazionale dei Tumori - Fondazione G.Pascale
    Naples, Italy
    Recruiting
  • Ospedale Santa Maria della Misericordia
    Perugia, Italy
    Recruiting
  • AOU di Cagliari Strada
    Monserrato, Cagliari, Italy
    Active not recruiting
  • Ospedale 'Guglielmo da Saliceto'
    Piacenza, PC, Italy
    Active not recruiting
  • Istituto Regina Elena per lo studio e la cura dei tumori
    Roma, Rm, Italy
    Active not recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.