Registry for pregnancy and fertility in young breast cancer patients
Official title: An Italian Multicenter Prospective Cohort Study on Fertility Preservation and Pregnancy Issues in Young Breast Cancer Patients: PREgnancy and FERtilty (PREFER)
Run by IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy · NCT02895165 · Data updated 2026-11-12
This study is trying to learn more about how young women with breast cancer can preserve their fertility and manage pregnancy-related issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 1000 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 23 sites (Asti, Asti and 22 other locations) |
| Status | Recruiting |
| Started | November 2012 |
| Main results expected | November 2027 |
| Study ends | November 2032 |
| Registry record updated | April 30, 2026 |
| Trial ID | NCT02895165 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include young women aged 18 to 45 with a breast cancer diagnosis who have not yet undergone radiation or chemotherapy.
✕Probably not a fit
Patients with stage IV breast cancer or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The PREgnancy and FERtility (PREFER) program is designed to enhance care and understanding of fertility preservation and pregnancy issues among young women diagnosed with breast cancer. It consists of two main components: PREFER-FERTILITY, which gathers data on fertility preservation preferences and outcomes, and PREFER-PREGNANCY, which focuses on pregnancy-related issues in this patient population. The initiative began at the National Institute for Cancer Research in Italy and has expanded to include multiple institutions under the Gruppo Italiano Mammella study group.
Why it matters
Potential benefit: If successful, this program could significantly improve fertility preservation options and pregnancy outcomes for young breast cancer patients.
How similar studies have gone: While the approach is comprehensive, similar studies have shown promise in addressing fertility and pregnancy issues in cancer patients, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * breast cancer diagnosis * age between18 and 45 years (only for PREFER-FERTILITY) * have not received any radiation or chemotherapy for cancer before enrolment (only for PREFER-FERTILITY) * absence of metastatic disease (only for PREFER-FERTILITY) * diagnosis of breast cancer during pregnancy or within 1 year from the end of pregnancy or pregnancy after prior diagnosis and treatment for breast cancer (only for PREFER-PREGNANCY) * informed consent Exclusion Criteria: * inability to provide written informed consent * stage IV disease at diagnosis (only for PREFER-FERTILITY) * serious psychiatric disorders
Where it's running
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Ospedale Cardinal Massaia
Asti, Asti, Italy Recruiting -
Presidio Ospedaliero 'Antonio Perrino'
Brindisi, Br, Italy Recruiting -
Azienda Ospedaliera S. Croce e Carle
Cuneo, Cn, Italy Recruiting -
Arcispedale S. Anna - A.O.U. di Ferrara
Cona, Fe, Italy Recruiting -
Irccs Aou San Martino - Ist
Genoa, Ge, Italy Recruiting -
Ospedale Vito Fazzi
Lecce, Le, Italy Recruiting
Show 17 more locations
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Ospedale Unico Versilia
Lido di Camaiore, Lu, Italy Recruiting -
Azienda Ospedaliera Carlo Poma
Mantua, Mn, Italy Recruiting -
AOU Pisana - Ospedale S. Chiara
Pisa, Pisa, Italy Recruiting -
Fondazione S. Maugeri IRCCS
Pavia, Pv, Italy Recruiting -
Azienda Ospedaliera S. Carlo
Potenza, Pz, Italy Recruiting -
Arcispedale Santa Maria Nuova di Reggio Emilia
Reggio Emilia, Reggio Emilia, Italy Recruiting -
Azienda Ospedaliera n. 1 - Annunziata
Sassari, Ss, Italy Recruiting -
Fondazione del Piemonte per l'Oncologia - IRCC di Candiolo
Candiolo, To, Italy Recruiting -
ASS1 Triestina
Trieste, Trieste, Italy Recruiting -
AOU SM Misericordia
Udine, Ud, Italy Recruiting -
Ospedale Sacro Cuore Don Calabria
Negrar, Ve, Italy Recruiting -
A.O.U. Federico II
Naples, Italy Recruiting -
Istituto Nazionale dei Tumori - Fondazione G.Pascale
Naples, Italy Recruiting -
Ospedale Santa Maria della Misericordia
Perugia, Italy Recruiting -
AOU di Cagliari Strada
Monserrato, Cagliari, Italy Active not recruiting -
Ospedale 'Guglielmo da Saliceto'
Piacenza, PC, Italy Active not recruiting -
Istituto Regina Elena per lo studio e la cura dei tumori
Roma, Rm, Italy Active not recruiting
Study contacts
- Study coordinator: Lucia Del Mastro, MD
- Email: lucia.delmastro@hsanmartino.it
- Phone: +390105558908
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.