Registry for identifying risk factors of esophageal cancer
Esophageal Cancer Risk Registry
This study is trying to find out if certain blood and tissue markers can help identify people at risk for esophageal cancer by looking at their medical history and samples.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 7000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT00260585 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify blood and tissue markers that indicate risk factors for esophageal cancer development and progression. Patients with esophageal disorders will provide medical history, blood, and tissue samples, which will be analyzed for genetic and behavioral risk factors. The study seeks to enhance early detection and prevention strategies for esophageal cancer by examining changes in genetic material and proteins. Participants will undergo questionnaires and sample collection during routine clinical visits.
Who should consider this trial
Good fit: Ideal candidates include individuals with known or suspected esophageal malignancies, Barrett's metaplasia, symptomatic GERD, achalasia, or hiatal hernia.
Not a fit: Patients with elevated pre-operative bloodwork or specific coagulation issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and prevention strategies for esophageal cancer, potentially increasing survival rates.
How similar studies have performed: Other studies have shown promise in identifying genetic markers for cancer risk, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Known or suspected esophageal or gastroesophageal junction malignancy * Known Barrett's metaplasia * Clinical management of symptomatic gastroesophageal reflux disease (GERD) * Achalasia * Hiatal hernia Exclusion Criteria: * Elevated pre-operative bloodwork will not have the additional biopsies taken. * Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken.
Where this trial is running
Pittsburgh, Pennsylvania
- Department of Cardiothoracic Surgery — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: James D. Luketich, MD — Department of Cardiothoracic Surgery
- Study coordinator: Julie A Ward, BSN
- Email: wardj@upmc.edu
- Phone: 412-647-8583
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.