Registry for Endovascular Thrombectomy in Extra-Large Stroke Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect data on the outcomes of endovascular thrombectomy in patients suffering from acute ischemic stroke with extra-large infarct cores, defined as having a volume greater than 100ml. It builds on previous randomized trials that have demonstrated the efficacy of thrombectomy in patients with large vessel occlusion. The study will enroll patients within 24 hours of stroke onset and will assess their eligibility based on specific imaging criteria. The goal is to better understand the safety and effectiveness of this intervention in a population that has been underrepresented in prior studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Clinical inclusion criteria

1. Age ≥18 years;
2. Presenting with acute ischemic stroke within 24 hours of time from last known well;
3. The patient or patient's representative signs a written informed consent form before enrollment.

Neuroimaging inclusion criteria

1. Occlusion of internal carotid artery, or the middle cerebral artery M1 or M2 segments confirmed by computed tomography angiography, magnetic resonance angiography, or digital subtraction angiography;
2. The baseline ASPECTS is 0 to 2 based on NCCT or diffusion weighted imaging, or cerebral extra-large ischemic core volume ≥85ml (defined as relative cerebral blood flow \<30% on CT perfusion or an apparent diffusion coefficient \<620×10\^-6 mm2/s on MRI).

Exclusion criteria

1. CT or MRI evidence of acute intracranial hemorrhage;
2. Evidence of mass effect with ventricular effacement, midline shift or herniation on baseline imaging;
3. Females who are pregnant, or those of childbearing, potential with positive urine or serum beta Human Chorionic Gonadotropin test;
4. Previous bleeding disorders, severe heart, liver or kidney disease, or sepsis;
5. Any terminal illness with life expectancy less than 6 months;
6. Participation in other clinical treatment trials.

Where it's running

• Xiangtan Central Hospital
  Xiangtan, Hunan, China Recruiting

Study contacts

• Principal investigator: Guangxiong Yuan — Xiangtan Central Hospital
• Study coordinator: Zhongming Qiu
• Email: qiuzhongmingdoctor@163.com
• Phone: +8613236599269

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.