Regenerative treatment for mandibular molar furcation defects using xenograft with enamel matrix derivative

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two regenerative surgical approaches for mandibular molar Class II furcation defects in adults with periodontitis. One group receives xenograft bone plus enamel matrix derivative (EMD); the other group receives xenograft bone plus a collagen membrane. Participants will be followed for about seven months to assess clinical parameters, imaging changes, and patient-reported outcomes such as pain and satisfaction. Before and after surgery, measurements include plaque and bleeding indices, pocket depth, attachment loss, and furcation defect volume and bone density by CBCT, with GCF TWEAK levels explored. The study plans 24 teeth from eligible participants, with random assignment to the two treatments and follow-ups at 2 weeks, 1 month, 3 months, and 6 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older.
* Full-mouth plaque score (FMPS) ≤ 20%.
* Full-mouth bleeding score (FMBS) ≤ 20%.
* Willingness to participate in the study and provide informed consent.
* Mandibular first and/or second molar with a buccal Class II furcation defect classified as subgroup A2 or B2.
* Probing pocket depth (PPD) ≥ 5 mm at the eligible furcation site.
* Keratinized gingival height ≥ 2 mm at the eligible site.
* No gingival recession extending apically beyond the buccal furcation roof; the furcation entrance must not be clinically exposed above the gingival margin.

Exclusion Criteria:

* Systemic diseases or conditions that may affect periodontal treatment outcomes, including uncontrolled diabetes mellitus, heart disease requiring anticoagulant therapy, hematologic disorders, or immunodeficiency.
* Pregnancy or breastfeeding.
* Untreated endodontic pathology involving the study tooth.
* Class III furcation involvement according to the Hamp classification.
* Untreated occlusal trauma involving the study tooth.
* Grade II tooth mobility that has not been stabilized by splinting, or Grade III tooth mobility according to the Miller classification.
* Defective restorations at the surgical site, including overhanging, bulky, or poorly adapted restorations.

Where it's running

• Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City
  Ho Chi Minh City, Binh Phu, Vietnam Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Minimally invasive treatment with i-PRF and xenograft for Class II furcation defects in mandibular molars

  This study tests whether using injectable platelet-rich fibrin (i-PRF) with or without a xenograft can improve healing for Class II furcation defects in lower molars after periodontal therapy.

  Recruiting Phase 3 Cairo University · Cairo, Cairo Governorate · NCT07876973

• Health education program to help depression in older adults and caregivers in Ho Chi Minh City

  A community-based education program for people 60+ and their caregivers is being tested to see if it can lower depression and improve quality of life compared with standard care.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Cho Lon · NCT07877571

• Mandibular molar furcation defects in advanced periodontitis: a regenerative treatment comparison

  In people with advanced gum disease, this study tests two regenerative treatments for Hamp Class II furcation defects in lower molars to see which works better and whether CBCT imaging matches what clinicians find during surgery.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT07770256

• A-PRF+ with Xenograft vs Collagen Membrane with Xenograft for Degree II Furcation Defects in Mandibular Molars

  This trial tests whether using advanced platelet-rich fibrin with a xenograft works better than a collagen membrane with a xenograft to treat degree II furcation defects in lower first molars of adults with periodontitis.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Ho Chi Minh City (HCMC) · NCT07764029

• Home-use dual-light antibacterial therapy for peri-implant mucositis around full-arch implants

  This study tests whether a home-use dual-light device added to standard care can better control gum inflammation around full-arch dental implants than standard care alone.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Cau Ong Lanh Ward · NCT07763431

• FARES vs. traction-countertraction for acute anterior shoulder dislocation

  This trial tests whether the FARES technique can reduce an acute anterior shoulder dislocation faster and with less pain than the traditional traction-countertraction method in adults.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Ho Chi Minh City · NCT07757594

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.