Reducing opioid-related deaths in Illinois

Justice Community Opioid Innovation Network (JCOIN): Reducing Opioid Mortality in Illinois

Not applicable Interventional University of Chicago · NCT04925427

This study is testing whether connecting people with a history of opioid use disorder, who are released from jails in Illinois, to intensive support and coaching can help them stay in treatment and improve their lives.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1500 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Chicago Academic / other
Locations5 sites (Chicago, Illinois and 4 other locations)
Trial IDNCT04925427 on ClinicalTrials.gov

What this trial studies

This research initiative, led by the University of Chicago in collaboration with various organizations, aims to connect individuals with a history of opioid use disorder, who are released from jails and prisons in Illinois, to effective substance use treatment. The study employs a randomized control trial design to evaluate the effectiveness of an intensive case management model and peer recovery coaching in improving treatment engagement and retention. It will also assess secondary outcomes such as insurance enrollment and re-arrest rates, while focusing on the differences in treatment engagement across urban and rural settings.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 18 and older with a history of opioid use disorder who are being released from designated jails or prisons in Illinois.

Not a fit: Patients who are experiencing cognitive impairments that prevent informed consent or those residing outside the service area may not benefit from this study.

Why it matters

Potential benefit: If successful, this initiative could significantly reduce opioid-related mortality and improve treatment outcomes for individuals with opioid use disorder.

How similar studies have performed: Other studies have shown success with similar approaches in linking individuals with opioid use disorder to treatment, indicating that this methodology is promising.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants must be at least 18 years old
* Reside in designated research site county or zip code
* Satisfy criteria for likely OUD based upon nonmedical use of prescription opioids, heroin, or synthetic opioids.

Exclusion Criteria:

* Participants experiencing cognitive impairments that preclude informed consent.
* Reside out of the service area.
* Prior enrollment in a parallel JCOIN study.

Where this trial is running

Chicago, Illinois and 4 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Opioid UseOpioid-use Disorder
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.