Recovery of physical function after critical illness in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational study following 150 ICU survivors from hospital discharge to 24 months later. Participants will undergo a battery of physical and functional tests at baseline (hospital discharge) and at 3, 6, 12, and 24 months, with a subset undergoing muscle biopsies at baseline and 12 or 24 months to explore cellular changes. The goal is to describe recovery trajectories and identify factors associated with persistent physical disability, including muscle oxidative stress and mitochondrial function. The study does not involve a treatment intervention but seeks to map long-term outcomes and underlying biology after critical illness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult patients (≥40 years of age)
* patients who have survived an ICU admission of at least 72 hours
* diagnosis of acute lung injury or sepsis are eligible.

Exclusion Criteria:

* individuals who were not ambulatory prior to ICU admission,
* not expected to survive at least 6 months,
* have a new or pre-existing brain infarct, injury, or neurological condition with deficits preventing participation in physical testing,
* have a pre-existing geriatric syndrome that were confound recovery trajectory

Where it's running

• University of Kentucky, Lexington, Kentucky 40536
  Lexington, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Kirby P Mayer, DPT, Ph.D. — University of Kentucky
• Study coordinator: Doug Long, MS
• Email: delong2@uky.edu
• Phone: 859-218-0596

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.