Rapid, multiplex microbiology–guided antibiotic stewardship in hospitalized adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares a protocolized antimicrobial stewardship approach that incorporates rapid multiplex molecular microbiology results with standard stewardship. It enrolls adults hospitalized on high‑impact empiric therapy and randomizes them to receive the protocolized strategy or usual care. Outcomes include duration of high‑impact antibiotic exposure, appropriateness of therapy, and clinical outcomes such as readmission, ICU care, infection recurrence, mortality, and costs. The study aims to identify how best to integrate rapid diagnostic results into real‑world stewardship decisions to optimize antimicrobial use. Recruitment occurs at Hospital General Universitario de Elche in Spain, with adult participants who consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Hospitalized in one of the participating study units at Hospital General Universitario de Elche.
* Initiation of empiric high-impact antimicrobial therapy subject to antimicrobial stewardship program (ASP) review.
* Provision of written informed consent by the participant or, when applicable, by a legally authorized representative.

Exclusion Criteria:

* Severe immunosuppression with profound neutropenia (\<100 neutrophils/mm³).
* Previous enrollment in this clinical trial.
* Expected survival of less than 48 hours.
* Documented microbiological identification of the presumed causative pathogen by conventional methods in a representative and/or sterile sample before randomization and before availability of multiplex molecular microbiology results.

Where it's running

• Hospital General Universitario de Elche
  Elche, Alicante, Spain Recruiting

Study contacts

• Study coordinator: María Espinosa Pérez, MD
• Email: espinosa_mariaper@gva.es
• Phone: +34 675047622

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Wastewater monitoring for antibiotic-resistant bacteria in nursing homes

  This project will test whether the amount of resistant bacteria in nursing home wastewater can indicate how many residents carry those bacteria.

  Recruiting at 2 sites Nantes University Hospital · Angers and 1 other locations · NCT07234331

• Monitoring antimicrobial resistance in pneumonia patients using metagenomics

  This study is trying to understand how different germs and their resistance to antibiotics affect patients with mild and severe pneumonia to improve diagnosis and treatment.

  Recruiting Shanghai General Hospital, China · Shanghai, Shanghai Municipality · NCT06566898

• Using azithromycin to reduce child mortality in Niger

  This study is testing whether giving a common antibiotic called azithromycin to children in Niger can help reduce the number of kids who die before age five while also keeping an eye on any risks of antibiotic resistance.

  Recruiting Phase 4 University of California, San Francisco · Niamey · NCT06358872

• Expanding HIV-positive donor livers for HIV-positive recipients

  This study tests whether liver transplants from HIV-positive donors to HIV-positive recipients are safe regarding opportunistic infections and cancer.

  Recruiting at 2 sites National Institute of Allergy and Infectious Diseases (NIAID) · Baltimore, Maryland and 1 other locations · NCT07778459

• Optimizing HIV Therapy for AIDS-Related Lymphoma Patients

  This study tests whether long-acting HIV medicines given during lymphoma treatment work better at keeping the virus suppressed than standard oral therapy in adults with AIDS-related lymphoma.

  Recruiting Shanghai Public Health Clinical Center · Shanghai, Shanghai Municipality · NCT07727642

• Colchicine to see if it reduces coronary artery inflammation in people with HIV

  This study tests whether low-dose colchicine can lower inflammation in the coronary arteries of people with HIV who are at high heart-disease risk, compared with a placebo.

  Recruiting at 2 sites Phase 2 Instituto de Investigación Hospital Universitario La Paz · Barcelona and 3 other locations · NCT07704164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.