Prophylactic Tamsulosin to Prevent Postoperative Urinary Retention After Rectal Resection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this double-blind, randomized trial, men undergoing rectal resection will receive either tamsulosin 0.4 mg once daily for five days before surgery plus the day after, or a matching placebo. All participants will have a Foley catheter during surgery and will be assessed for postoperative urinary retention based on urine flow, bladder volume, and symptoms within 30 days after surgery. Primary outcomes include the incidence of postoperative urinary retention and the efficacy of prophylaxis; secondary outcomes cover length of hospital stay, number of catheterizations, and total catheter duration. Recruitment occurs at two Quebec hospitals, with follow-up through clinical teams and a patient logbook.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male patients
* 18 years and older
* Scheduled for rectal resection during the study period.

Exclusion Criteria:

* Patients undergoing revisional surgery
* Patients taking alpha-blocker medication,
* Patients who have an indwelling urinary catheter,
* Patients who have undergone urinary tract surgery,
* Patients who will have an intraoperative trauma of the urinary tract,
* Patients who will keep their urinary catheter for more than 24 hours after surgery,
* Patients who have an intolerance to alpha-blocking drugs or who take one of the following drugs (potential interaction): anti-retroviral, antifungal, clarithromycin, erythromycin, paroxetine, terbinafine, cimetidine, coumadin or phosphodiesterase inhibitors.
* Patients who will have an epidural anesthesia

Where it's running

• Hôpital Saint-François d'Assise
  Québec, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Frédérique Beauchamp, MD
• Study coordinator: Frédérique Beauchamp, MD
• Email: frederique.beauchamp.1@ulaval.ca
• Phone: 4182717881

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.