Prognosis of Infectious Endocarditis
Official title: Study of the Prognosis of Infectious Endocarditis (EPEI): Prospective and Retrospective Follow-up of a Cohort of Patients Hospitalized for Infectious Endocarditis
Run by Centre Hospitalier Universitaire, Amiens · NCT03211975 · Data updated 2026-11-12
This study looks at how infectious endocarditis affects people with both natural and artificial heart valves to better understand the disease and improve treatment outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 645 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens, Picardie) |
| Status | Recruiting |
| Started | February 27, 2017 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT03211975 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with infectious endocarditis who meet Duke's criteria.
✕Probably not a fit
Patients with infections that do not meet the Duke criteria for infectious endocarditis will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the prognosis of infectious endocarditis, focusing on both native valves and prosthetic valves. It aims to understand the evolution of this complex disease, which has seen changes in epidemiology and risk factors in recent years. The study will include patients diagnosed with infectious endocarditis according to Duke's criteria, confirmed through imaging or surgical specimens. By analyzing these cases, the study seeks to provide insights into the management and outcomes of this condition.
Why it matters
Potential benefit: If successful, this study could improve the understanding and management of infectious endocarditis, potentially leading to better patient outcomes.
How similar studies have gone: While there have been studies on infectious endocarditis, this specific focus on the prognosis related to evolving risk factors is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients with certain infectious endocarditis according to Duke's criteria, confirmed by the presence of evocative images on the transthoracic and / or transesophageal ultrasound or by the data collected on the surgical specimens. Exclusion Criteria: * Patients with an infection not meeting the Duke IE criteria.
Where it's running
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CHU Amiens Picardie
Amiens, Picardie, France Recruiting
Study contacts
- Study coordinator: Christophe TRIBOUILLOY, PhD
- Email: tribouilloy.christophe@chu-amiens.fr
- Phone: +33322455885
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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San Matteo Endocarditis Registry (STEADY)
This registry collects health and treatment information from people diagnosed with infective endocarditis at San Matteo to better understand their care and outcomes.
-
Continuous versus standard intermittent ampicillin plus ceftriaxone for Enterococcus faecalis endocarditis
This study will see if giving ampicillin plus ceftriaxone as a continuous infusion works as well and is as safe as the usual intermittent dosing for adults with Enterococcus faecalis infective endocarditis.
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Comparing oral antibiotics to outpatient parenteral therapy for infective endocarditis
This study is testing if taking oral antibiotics at home is just as effective as getting antibiotics through an IV for patients with left-sided infective endocarditis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.