Preventing malaria after flooding in Uganda
After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding
This study is testing different ways to prevent malaria in villages in Uganda that have been flooded, by providing new bed nets and sometimes medication to see what works best.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36000 (estimated) |
| Ages | 2 Years to 99 Years |
| Sex | All |
| Sponsor | University of North Carolina, Chapel Hill Academic / other |
| Locations | 1 site (Mbarara) |
| Trial ID | NCT06870344 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate various strategies for preventing malaria infections in villages affected by severe flooding in western Uganda. Investigators will implement an open-label, cluster randomized controlled trial across approximately 50-60 villages, where residents will receive new bed nets and, in some cases, monthly medication or treatments to reduce mosquito breeding. The study will monitor malaria incidence and mosquito populations over a 12-month period following flooding, utilizing baseline surveys to stratify risk based on malaria transmission intensity. The goal is to identify the most effective intervention strategies to mitigate malaria outbreaks in flood-prone areas.
Who should consider this trial
Good fit: Ideal candidates are permanent residents of flood-prone villages in Kasese District who can commit to the study procedures.
Not a fit: Patients who are temporary or part-time residents of the study villages may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce malaria infections in communities affected by flooding, improving public health outcomes.
How similar studies have performed: Other studies have shown success in using similar preventive strategies against malaria in endemic regions, indicating potential for positive outcomes in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Permanent resident of flood-prone village in Kasese District with no plans to change residency in subsequent 12 months * Able and willing to comply with all study procedures and be available for the duration of the study * Able and willing to consent to study procedures as documented on informed consent form (ICF). For children (age \<18 years), parent or guardian must provide consent. Children age ≥8 to 17 years will also be asked to provide written assent. Exclusion Criteria: * Temporary or part-time residence in study village * Plans to move in the next 12 months * Unable or unwilling to provide consent. * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.
Where this trial is running
Mbarara
- Mbarara University of Science and Technology (MUST) — Mbarara, Uganda (Recruiting)
Study contacts
- Principal investigator: Ross Royce, MD, M.Sc. — University of North Carolina, Chapel Hill
- Study coordinator: Ross Boyce, MD, M.Sc.
- Email: roboyce@med.unc.edu
- Phone: 9199320688
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.