PrEP given with opioid replacement therapy at community pharmacies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In Alberta and Saskatchewan the program offers oral PrEP alongside ongoing opioid agonist therapy through existing pharmacy-based OAT programs to see if co-delivery is practical. HIV-negative participants who are regularly engaged in OAT (at least three days per week) and report behaviors that could expose them to HIV will be enrolled and followed. The study will collect data on preferences, adherence, and persistence with oral PrEP and will ask about interest in long-acting injectable PrEP options. Safety exclusions include significant renal impairment or other contraindications to tenofovir-based PrEP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* HIV negative
* Ongoing behaviors with potential HIV exposure as assessed by a clinician
* Regularly engaged with their respective OAT program at least 3 days a week for the past 2 weeks
* Report willingness to return for follow-up visits

Exclusion Criteria:

* Creatine clearance \<30 mL/min or any medical condition or medication known to be contraindicated with the use of Emtricitabine/Tenofovir Alafenamide (F/TAF) or Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF)
* Taken PrEP within the last 24 hours at the time of screening or enrollment
* Deemed appropriate by a clinician for HIV Post-Exposure Prophylaxis at the time of screening or enrollment

Where it's running

• Mayfair Drugs Pharmacy
  Saskatoon, Saskatchewan, Canada Recruiting
• Pharmasave Riversdale Pharmacy
  Saskatoon, Saskatchewan, Canada Recruiting
• The Medicine Shoppe Pharmacy
  Saskatoon, Saskatchewan, Canada Recruiting
• Meadowgreen Pharmacy
  Saskatoon, Saskatchewan, Canada Recruiting
• Sheldon M Chumir Health Centre
  Calgary, Alberta, Canada Not yet recruiting
• Queen City Wellness Pharmacy
  Regina, Saskatchewan, Canada Not yet recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.