Preoperative nutrition and iron optimization for children having hip osteotomy
Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation (PORPOISE)
See if a pre-surgery nutrition program with iron supplements helps children (0–18) having varus-derotation or pelvic osteotomy, especially those with cerebral palsy, by reducing blood transfusions and improving recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 0 Years to 18 Years |
| Sex | All |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT07095244 on ClinicalTrials.gov |
What this trial studies
This interventional program implements a multidisciplinary preoperative nutrition pathway for children scheduled for varus-derotation osteotomy (VDRO) or pelvic osteotomy, incorporating iron deficiency screening and iron supplementation when indicated. The project enrolls a prospective cohort receiving the nutrition intervention and compares outcomes to a historical cohort of patients operated on between February 2022 and December 2024. Primary outcome is incidence of perioperative blood transfusion, with secondary outcomes including other perioperative surgical outcomes, feasibility, and family acceptability. The intervention is delivered at BC Children's Hospital and targets nutritional optimization before the planned >4-hour procedures.
Who should consider this trial
Good fit: Children aged 0–18 years scheduled for VDRO and/or pelvic osteotomy, including those with cerebral palsy or other neuromotor conditions, particularly if they have low iron or iron-deficiency anemia.
Not a fit: Patients who cannot take oral/enteral iron, have recent major surgery or recent iron-directed nutritional treatment, have bleeding disorders, are taking erythropoietin, or cannot participate due to language barriers may not receive benefit from this program.
Why it matters
Potential benefit: If successful, the program could lower the need for perioperative blood transfusions and improve surgical recovery for pediatric VDRO/pelvic osteotomy patients.
How similar studies have performed: Adult patient blood management programs and some small pediatric reports have shown that perioperative iron repletion can reduce transfusion rates, but comprehensive pediatric implementations like this are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients scheduled for VDRO and/or pelvic osteotomy surgery (prospective cohort) * All patients who had VDRO and/or pelvic osteotomy surgery between February 2022 and December 2024 (historical cohort) * Ages 0-18 years old Note that the investigators will include patients who do or do not have a diagnosis of a neuromotor condition. The investigators may not include patients who are enrolled in other conflicting research studies. Exclusion Criteria: * Patients who have undergone a major surgical intervention in the last 3 months * Patients who have received a nutritional intervention that includes iron testing and treatment within the last 3 months * Patients in whom oral/enteral iron supplementation is contraindicated * Patients who have a bleeding disorder * Patients taking erythropoietin * Patients who cannot read and understand English\* * Patients and their families who cannot read and understand English will be excluded from the study because the surveys and interviews are conducted in English. These patients will still have access to the same nutrition management and interventions as study participants.
Where this trial is running
Vancouver, British Columbia
- BC Children's Hospital — Vancouver, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Teresa Skelton, MD — University of British Columbia
- Study coordinator: Katherine L Mason, BSc
- Email: katherine.mason@bcchr.ca
- Phone: 604-875-2000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.