Preoperative chemoradiation for glioblastoma treatment

Phase II Study of Neoadjuvant Chemoradiation for Resectable Glioblastoma (NeoGlio)

This study is testing if giving chemotherapy and radiation before surgery can help people with glioblastoma have better outcomes and live longer.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 18 Years to 89 Years
• Sex: All
• Sponsor: Geisinger Clinic (Academic / other)
• Drugs / interventions: chemotherapy, radiation
• Locations: 2 sites (Danville, Pennsylvania and 1 other locations)
• Trial ID: NCT04209790 on ClinicalTrials.gov

What this trial studies

This Phase II interventional study aims to evaluate the feasibility and efficacy of neoadjuvant chemoradiation in patients with resectable glioblastoma. The study will assess whether administering chemotherapy and radiation before surgery can improve local disease control and overall survival rates. Utilizing a two-phase design, the trial will monitor progression-free survival and local progression rates, with the goal of determining if this new treatment approach is promising enough to warrant further controlled clinical evaluations. The anticipated outcomes are based on previous literature and aim to significantly enhance patient prognosis compared to standard care.

Who should consider this trial

Good fit: Ideal candidates include individuals with newly diagnosed glioblastoma who are suitable for surgical resection and have a Karnofsky Performance Status greater than 70.

Not a fit: Patients who are not suitable for surgery or have contraindications for chemoradiation will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved survival rates and better local control of glioblastoma in patients undergoing surgery.

How similar studies have performed: Previous studies in other cancer types have shown that neoadjuvant chemoradiation can improve outcomes, but this specific approach in glioblastoma is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Newly diagnosed GBM with histopathological confirmation.
2. Surgically suitable for subtotal or gross total resection as determined by central review.
3. Karnofsky Performance Status (KPS)\>70
4. No contraindication for chemoradiation.
5. Complete blood count (CBC)/differential obtained within 28 days prior to registration, with adequate bone marrow function defined as follows:

   1. Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3;
   2. Platelets ≥ 100,000 cells/mm3;
   3. Hemoglobin ≥ 8.0 g/dl (Note: the use of transfusion or other intervention to achieve Hgb ≥8.0 g/dl is acceptable)
6. Adequate hepatic function within 28 days prior to registration, as defined below:

   1. Alanine Aminotransferase (ALT) and Aspartate transaminase (AST) ≤ 3 x ULN
   2. Bilirubin ≤ 1.5 upper limit of normal (ULN)
7. Negative serum pregnancy test obtained for females of child-bearing potential within 28 days prior to step 2 registration.
8. Ability to get multiplanar contrast enhanced Magnetic Resonance Imaging (MRI)

Exclusion Criteria:

1. Recurrent, unresectable or multifocal malignant gliomas.
2. Any site of distant disease (for example, drop metastases from the GBM tumor site)
3. Prior radiation or chemotherapy or radiosensitizers for cancers of the brain and head and neck region; note that prior chemotherapy for a different cancer is allowable (except temozolomide).
4. Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic.
5. Patents treated on any other therapeutic clinical protocols within 30 days prior to registration.
6. Inability to undergo MRI (e.g., due to safety reasons, such as presence of a pacemaker, or severe claustrophobia).
7. Severe, active co-morbidity, defined as follows:

   1. Transmural myocardial infarction within the last 6 months prior to registration
   2. History of recent myocardial infarction 1month prior
   3. New York Heart Association grade II or greater congestive heart failure requiring hospitalization within 3 months prior to registration.
   4. Serious or non-healing wound, ulcer or bone fracture or history of abdominal fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to registration, with the exception of the craniotomy for surgical resection
   5. Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
   6. Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol.
   7. Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
   8. Acquired immune deficiency syndrome (AIDS) based upon current Center for Disease Control (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is because the treatments involved in this protocol may be significantly immunosuppressive with potentially fatal outcomes in patients already immunosuppressed.
   9. Any other severe immuno-compromised condition.
   10. Active connective tissue disorders, such as lupus or scleroderma that in the opinion of the treating physician may put the patient at high risk for radiation toxicity.
   11. End-stage renal disease (i.e. on dialysis or dialysis has been recommended).
   12. Any other major medical illnesses or psychiatric treatments that in the investigator's opinion will prevent administration or completion of protocol therapy.

Where this trial is running

Danville, Pennsylvania and 1 other locations

• Geisinger Medical Center — Danville, Pennsylvania, United States (Recruiting)
• Geisinger Wyoming Valley Medical Center — Wilkes-Barre, Pennsylvania, United States (Recruiting)

Study contacts

• Principal investigator: Anand Mahadevan, M.D. — Geisinger Clinic
• Study coordinator: Heather Albertson, RN, BSN

Conditions Glioblastoma; Surgery; High Grade Glioma