Predicting the risk of heart artery disease after a heart attack
Optical Coherence Tomography With Magnetic Resonance Angiography to Assess STEMI Non-culprit Risk
This study is testing new imaging methods to see if they can help identify which patients who had a heart attack are at risk for more heart artery problems that might need treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Guy's and St Thomas' NHS Foundation Trust Academic / other |
| Locations | 2 sites (London and 1 other locations) |
| Trial ID | NCT05781087 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the risk of non-culprit coronary artery disease in patients who have recently experienced a heart attack. Participants will undergo advanced imaging techniques, including optical coherence tomography and magnetic resonance angiography, to evaluate the severity of narrowings in their coronary arteries. The goal is to determine which non-culprit narrowings are likely to progress and require treatment, thereby avoiding unnecessary procedures for stable conditions. By accurately predicting the risk, the study seeks to improve patient outcomes and treatment strategies.
Who should consider this trial
Good fit: Ideal candidates are individuals who have had a successful primary percutaneous coronary intervention for a heart attack and have non-culprit disease planned for further evaluation.
Not a fit: Patients with severe complications from their heart attack, such as cardiogenic shock or those with significant comorbidities, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized treatment approaches for patients with coronary artery disease, reducing unnecessary interventions and associated risks.
How similar studies have performed: Other studies utilizing advanced imaging techniques for coronary artery disease assessment have shown promise, indicating that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Successful primary percutaneous coronary intervention (PCI) within the previous week with no major complications at the index procedure * Bystander disease in a non-culprit vessel planned for clinically indicated staged angiography +/- PCI * Able to provide written informed consent. Exclusion Criteria: * Cardiogenic shock requiring intubation, inotropes or a mechanical support device * Creatinine clearance \<30ml/min * Prior coronary artery bypass grafting * Life expectancy less than 3 years * Pregnancy. * Target lesion in the left main coronary artery * Severe calcification or tortuosity that would threaten safe placement of a pressure wire or OCT catheter * Chronic total occlusion of a major epicardial vessel.
Where this trial is running
London and 1 other locations
- St Thomas' Hospital — London, United Kingdom (Recruiting)
- King's College Hospital — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Divaka Perera, MD — King's College London
- Study coordinator: Matthew Li Kam Wa, MBBS
- Email: mlikamwa@nhs.net
- Phone: 02071887188
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.