Predicting long-term cognitive issues and delirium after heart surgery
A Prediction Model of Long-term Postoperative Cognitive Dysfunction and Delirium After Cardiac Surgery Based on Peripheral Blood Biomarkers： A Prospective Cohort Study(PPSB)
RenJi Hospital · NCT05972057
This study is trying to see if it can predict which older patients might have memory problems or confusion after heart surgery to help improve their care and recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | RenJi Hospital (other) |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT05972057 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop a prediction model for long-term cognitive dysfunction and delirium in patients aged 65 and older undergoing elective cardiac surgery with cardiopulmonary bypass. It focuses on understanding the prevalence of delirium and its impact on cognitive function post-surgery, as previous studies indicate a significant risk of cognitive decline in this population. By identifying patients at risk, the study seeks to improve postoperative care and outcomes for elderly patients. The methodology involves assessing cognitive function and delirium occurrence in the specified patient group following their surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 65 and older who are scheduled for elective cardiac surgery with cardiopulmonary bypass.
Not a fit: Patients with serious dementia, neurological diseases, or those unable to complete neurocognitive tests may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing and managing cognitive dysfunction and delirium in elderly cardiac surgery patients.
How similar studies have performed: Previous studies have indicated a high prevalence of delirium in similar patient populations, suggesting that this approach could yield valuable insights, although the specific prediction model being developed may be novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 65 years * Patients undergoing elective cardiac surgery with cardiopulmonary bypass * Sign informed consent Exclusion Criteria: * serious dementia, encephalopathy, mental illness or other neurological diseases * Patients who could not take neurocognitive tests due to other reasons ( such as language, hearing or visual impairment ) * Patients with stage 3 or 4 malignant tumors, and patients with pancreatic cancer, gallbladder cancer, cholangiocarcinoma and other tumors with high malignancy and expected survival time less than 1 year * American Society of Anesthesiologists ( ASA ) classification IV or V patients
Where this trial is running
Shanghai, Shanghai
- Renji Hospital, Shanghai Jiao Tong University, School of Medicine — Shanghai, Shanghai, China (RECRUITING)
Study contacts
- Study coordinator: Li Peiying, Ph.D.
- Email: peiyingli.md@gmail.com
- Phone: +8615800616866
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Delirium, Cognitive Dysfunction