Predicting diabetes after kidney transplant using microRNA
Predicting Outcomes in Posttransplant Diabetes Mellitus Via microRNA
We will test whether specific microRNA patterns measured three months after a kidney transplant can predict which adult transplant recipients will develop diabetes in the following one to two years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Martin Academic / other |
| Locations | 2 sites (Martin and 1 other locations) |
| Trial ID | NCT07055984 on ClinicalTrials.gov |
What this trial studies
This observational study will collect blood samples from adult kidney transplant recipients without prior diabetes and measure microRNA profiles three months after transplantation. Participants will be followed for one to two years to record new-onset post-transplant diabetes mellitus (PTDM) and related clinical events. Researchers will combine microRNA data with traditional risk factors — including age, immunosuppressive regimen, obesity, and CMV infection — to develop predictive models. The aim is to find early molecular indicators that could prompt closer monitoring or preventive measures.
Who should consider this trial
Good fit: Adult kidney transplant recipients without pre-existing type 1 or type 2 diabetes who can give informed consent and attend follow-up visits.
Not a fit: Patients with pre-existing diabetes, prior organ transplants, severe comorbidities that confound PTDM assessment (such as pancreatic disease), or inability to consent are unlikely to benefit from the study's predictive biomarkers.
Why it matters
Potential benefit: If successful, the approach could allow earlier identification of patients at risk for post-transplant diabetes, enabling timely monitoring and individualized preventive steps to reduce complications.
How similar studies have performed: Some pilot studies have reported associations between microRNA signatures and diabetes risk after transplant, but larger validation studies remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients undergoing kidney transplantation. * Absence of pre-existing type 1 or type 2 diabetes mellitus. * Willingness to provide informed consent and comply with study procedures. Exclusion Criteria: * Pre-existing type 1 or type 2 diabetes mellitus. * Previous organ transplantation. * Severe comorbidities that could confound the assessment of PTDM (e.g., pancreatic disease). * Inability to provide informed consent.
Where this trial is running
Martin and 1 other locations
- Transplant-nephorlogy department — Martin, Slovakia (Recruiting)
- University hospital Martin — Martin, Slovakia (Recruiting)
Study contacts
- Study coordinator: Ivana Dedinska, prof, MD, PhD.
- Email: ivana.dedinska@uniba.sk
- Phone: +421 43 4203 920
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.