Predicting Colorectal Adenoma Recurrence and Cancer Risk Using Integrated TCM and Western Data
Official title: Study on the Prediction Model of Recurrence and Carcinogenesis Risk of Colorectal Adenoma Based on the Fusion of Traditional Chinese and Western Medicine Multimodal Features
Run by Beijing Friendship Hospital · NCT07611266 · Data updated 2026-11-12
This study tests a risk-prediction model that combines Traditional Chinese Medicine and Western medical features to see if it can forecast recurrence and malignant change in colorectal adenomas.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Beijing Friendship Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | May 30, 2028 |
| Study ends | November 30, 2028 |
| Registry record updated | May 28, 2026 |
| Trial ID | NCT07611266 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with diagnosed colorectal adenomas who consent to regular follow-up and multidisciplinary assessment.
✕Probably not a fit
Patients not matching the diagnostic criteria or those unlikely to benefit from predictive stratification may not derive improvement.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will build and validate a predictive model using data from multiple centers, gathering both TCM and Western clinical features. The study plans a large, multicenter cohort with clearly defined sample size calculations and separate training and validation sets. Participants will be adults with colorectal adenomas, followed over time with colonoscopies and lab tests, while standardized diagnostic criteria from both medical systems are applied. Data quality will be maintained through careful monitoring and follow-up, and various algorithms will be explored for model development.
Why it matters
Potential benefit: If successful, the model could help clinicians identify patients at higher risk of recurrence or malignant transformation and tailor surveillance accordingly.
How similar studies have gone: Previous work has shown potential for integrated multimodal data to improve risk prediction, but this specific TCM-Western fusion approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Meet the diagnostic criteria for colorectal adenoma (Western medicine) and the relevant TCM syndromes. * Aged 18 years or older. * Willing to undergo regular follow-up examinations (including colonoscopy and laboratory tests) and sign the informed consent form. Exclusion Criteria: * Pregnant or lactating women. * History of Crohn's disease, ulcerative colitis, or other malignancies. * Previous history of radiotherapy, chemotherapy, or gastrointestinal surgery. * Hereditary polyposis syndromes (e.g., familial adenomatous polyposis, MUTYH-associated polyposis, or hamartomatous polyposis syndrome). * Severe cognitive impairment, dementia, or mental illness. * Severe cardiovascular or cerebrovascular diseases, or hematological system disorders.
Where it's running
-
Beijing Friendship Hospital Affiliated to Capital Medical University
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Hongtao Wei
- Email: gulvzhe@126.com
- Phone: +86 13811216906
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.