Predicting cancer risk in oral leukoplakia using MAGE-A markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the potential of MAGE-A gene family antigens as predictive markers for the malignant transformation of oral leukoplakia (OLP). Given that a significant percentage of oral squamous cell carcinomas (OSCC) arise from OLP, early detection is crucial for improving patient outcomes. The study will assess the presence of MAGE-A antigens in patients diagnosed with OLP to determine their risk of developing OSCC. By identifying high-risk lesions, the study seeks to enhance therapeutic decision-making and potentially guide immunotherapy approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults, consenting male or female patients
* Age 18 - 80 years
* Diagnosis of one or more leukoplakia of the oral cavity

including

* leukoplakia associated wit lichen planus OR
* leukoplakia associated with diseases of the immune system or immunosuppression OR
* leukoplakia associated with a malignoma of other sites (except oral cavity) in the anamnesis
* Existing consent to participation in the study after clarification has been given

Exclusion Criteria:

* clinical evidence of invasive carcinoma of the oral cavity OR
* carcinoma of the oral cavity in the anamnesis OR
* patients unable to give informed consent OR
* rejection of the patient

Where it's running

• Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg
  Erlangen, Germany Recruiting

Study contacts

• Study coordinator: Manuel Weber, MD, DMD
• Email: manuel.weber@uk-erlangen.de
• Phone: 0049 9131 85 43749

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.