Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Pre-surgery strength program for adults with ACL tears

Official title: Comparison of Two Programs Delivered During Rehabilitation Before an Anteriror Cruciate Ligament Reconstruction : a Randomised Controlled Trial K-POP

Run by Nantes University Hospital · NCT07411625 · Data updated 2026-11-12

This project will test whether a 9-week progressive resistance training program before ACL reconstruction can increase knee muscle strength and size in adults waiting for surgery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment84 (estimated)
SponsorNantes University Hospital
Academic / other
Locations1 site (Nantes)
StatusRecruiting
StartedMarch 17, 2026
Main results expectedAugust 15, 2027
Study endsAugust 15, 2027
Registry record updatedMarch 20, 2026
Trial IDNCT07411625 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) with a first-time ACL tear scheduled for ACL reconstruction at least 10 weeks later, with a prescription for prehabilitation and the ability to attend one of the participating clinics.

Probably not a fit

People with prior ACL reconstructions, surgery scheduled sooner than 10 weeks, significant knee range-of-motion limitations, medical contraindications to high-load resistance training, or who cannot attend the participating clinics are unlikely to benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults awaiting ACL reconstruction are randomly assigned to a 9-week progressive resistance training program or to usual preoperative exercises delivered in outpatient rehabilitation clinics. The resistance program uses three progressive 3-week blocks with exercises performed close to failure to increase knee extensor and flexor maximal strength and induce hypertrophy. The trial recruits patients scheduled for ACLR at least 10 weeks out who have a medical prescription for prehabilitation and can attend one of the participating clinics. Primary aims are to increase muscle strength and volume prior to surgery to optimize postoperative recovery.

Why it matters

Potential benefit: If successful, the program could increase knee muscle strength and size before surgery, which may speed postoperative recovery and improve functional outcomes.

How similar studies have gone: Previous prehabilitation studies have produced modest preoperative gains in strength and function, but evidence is mixed and high-load, hypertrophy-focused preoperative programs are less well studied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Being over 18 years
* A first episode of an ACL injury
* An ACLR scheduled at least 10 weeks later, with a surgical technique using hamstring, gracilis, or quadriceps/patellar tendon autograft
* A minimum passive range of motion of the knee between 10° of extension deficit, and 80° of flexion
* A medical prescription for prehabilitation
* Possibility to attend prehabilitation program and post-ACLR rehabilitation in one of the 15 clinics

Where it's running

  • University Hospital - Laboratoire "Motricité, Interactions, Performance" (UR 4334)
    Nantes, France
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.