Synovial tissue biomarker study to guide PVNS management

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective study collects synovial tissue from adults with localized or diffuse PVNS undergoing therapy. The biopsies are used for diagnostic confirmation and research, including histology, immunohistochemistry, and high-throughput analyses. Participants are followed for one year with two visits (6 months and 12 months) to evaluate pain, function, and treatment response, then followed as per routine care for up to four years. The primary goal is to establish a patient biocollection and tissue quality suitable for biomarker discovery, with secondary aims assessing biopsy tolerance, patient acceptability, and the impact of treatments on synovial explants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient \>18 years
* Diagnosis of localized or diffuse villonodular synovitis
* Referred for therapeutic management
* Affiliated with or benefiting from a social security scheme

Exclusion Criteria:

* Pregnant women
* Nursing mothers
* Protected patients: patients under guardianship or curatorship, safeguard of justice
* Patients deprived of liberty
* Curative anticoagulation
* Thrombocytopenia \< 50,000 platelets/mm3

Where it's running

• CHU de Nantes
  Nantes, France Recruiting
• Hospices Civils de Lyon
  Lyon, France Not yet recruiting
• Hôpital Cochin APHP
  Paris, France Not yet recruiting

Study contacts

• Study coordinator: Benoit Le Goff, PU-PH
• Email: benoit.legoff@chu-nantes.fr
• Phone: 02 40 08 48 25

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.