Pre- and postoperative positive expiratory pressure (PEP) chest therapy to prevent hospital-acquired pneumonia
Pre- and Postoperative Chest Therapy With Positive Expiratory Pressure (PEP) to Prevent Hospital-acquired Pneumonia in Patients Undergoing Hip Fracture Surgery
This will see if using positive expiratory pressure (PEP) chest therapy before and after hip fracture surgery prevents hospital-acquired pneumonia in patients who can give informed consent.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 566 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Bispebjerg and Frederiksberg Academic / other |
| Locations | 2 sites (Copenhagen and 1 other locations) |
| Trial ID | NCT07189260 on ClinicalTrials.gov |
What this trial studies
This randomized interventional study compares systematic PEP chest therapy given before and after surgery with usual care alone in patients admitted with a hip fracture. Participants in the PEP arm will be asked to perform PEP therapy four times daily during hospitalization and log each session and any reasons for missed sessions on a paper checklist. The trial excludes patients with pneumonia or delirium on admission, pneumothorax, or those unable to consent, and enrolls cognitively well-functioning Danish-speaking residents of two Danish regions. Investigators will also collect information on barriers to performing PEP therapy in this patient group.
Who should consider this trial
Good fit: Ideal candidates are cognitively well-functioning adults with a hip fracture who can understand Danish, give informed consent, and are residents of Region Hovedstaden or Region Sjælland.
Not a fit: Patients with existing pneumonia, delirium, pneumothorax, or those unable to consent or perform the therapy are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the approach could reduce the number of hospital-acquired pneumonia cases after hip fracture and lower related complications and hospital stays.
How similar studies have performed: Some perioperative respiratory-therapy trials (mainly after abdominal or thoracic surgery) have shown reduced pulmonary complications, but evidence specifically in hip-fracture patients is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hip fracture regardless of age * Cognitively well-functioning * Able to understand the study and give informed consent * Able to speak and understand Danish * Resident of Region Hovedstaden or Region Sjælland Exclusion Criteria: * Cognitively impaired * Unable to understand the study and give informed consent * Pneumonia upon admission * Delirium upon admission * Pneumothorax For patients with e.g. dementia or brain injury, the ability to give informed consent will be assessed individually.
Where this trial is running
Copenhagen and 1 other locations
- Bispebjerg & Frederiksberg Hospital — Copenhagen, Denmark (Recruiting)
- Herlev & Gentofte Hospital — Herlev, Denmark (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.