Pre- and postoperative positive expiratory pressure (PEP) chest therapy to prevent hospital-acquired pneumonia
Official title: Pre- and Postoperative Chest Therapy With Positive Expiratory Pressure (PEP) to Prevent Hospital-acquired Pneumonia in Patients Undergoing Hip Fracture Surgery
Run by University Hospital Bispebjerg and Frederiksberg · NCT07189260 · Data updated 2026-11-12
This will see if using positive expiratory pressure (PEP) chest therapy before and after hip fracture surgery prevents hospital-acquired pneumonia in patients who can give informed consent.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 566 (estimated) |
| Sponsor | University Hospital Bispebjerg and Frederiksberg Academic / other |
| Locations | 2 sites (Copenhagen and 1 other locations) |
| Status | Recruiting |
| Started | February 19, 2024 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2030 |
| Registry record updated | September 23, 2025 |
| Trial ID | NCT07189260 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are cognitively well-functioning adults with a hip fracture who can understand Danish, give informed consent, and are residents of Region Hovedstaden or Region Sjælland.
✕Probably not a fit
Patients with existing pneumonia, delirium, pneumothorax, or those unable to consent or perform the therapy are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional study compares systematic PEP chest therapy given before and after surgery with usual care alone in patients admitted with a hip fracture. Participants in the PEP arm will be asked to perform PEP therapy four times daily during hospitalization and log each session and any reasons for missed sessions on a paper checklist. The trial excludes patients with pneumonia or delirium on admission, pneumothorax, or those unable to consent, and enrolls cognitively well-functioning Danish-speaking residents of two Danish regions. Investigators will also collect information on barriers to performing PEP therapy in this patient group.
Why it matters
Potential benefit: If successful, the approach could reduce the number of hospital-acquired pneumonia cases after hip fracture and lower related complications and hospital stays.
How similar studies have gone: Some perioperative respiratory-therapy trials (mainly after abdominal or thoracic surgery) have shown reduced pulmonary complications, but evidence specifically in hip-fracture patients is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hip fracture regardless of age * Cognitively well-functioning * Able to understand the study and give informed consent * Able to speak and understand Danish * Resident of Region Hovedstaden or Region Sjælland Exclusion Criteria: * Cognitively impaired * Unable to understand the study and give informed consent * Pneumonia upon admission * Delirium upon admission * Pneumothorax For patients with e.g. dementia or brain injury, the ability to give informed consent will be assessed individually.
Where it's running
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Bispebjerg & Frederiksberg Hospital
Copenhagen, Denmark Recruiting -
Herlev & Gentofte Hospital
Herlev, Denmark Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.