Clinical trial Recruiting at 1 site Interventional Ages 25 to 40

Post-Isometric Relaxation vs Reciprocal Inhibition for Piriformis Syndrome

Official title: Comparative Effects of Post-Isometric Relaxation and Reciprocal Inhibition Muscle Energy Techniques on Pain, ROM and Function in Piriformis Syndrome

Run by Riphah International University · NCT07646314 · Data updated 2026-11-12

A controlled trial tests two manual therapy techniques to see which helps people with piriformis syndrome more when used with standard physiotherapy.

More Piriformis Syndrome trials

Quick facts

Study typeInterventional
Ages25 Years to 40 Years
SexAll
Enrollment42 (estimated)
SponsorRiphah International University
Academic / other
Locations1 site (Lahore, Punjab Province)
StatusRecruiting
StartedAugust 1, 2026
Main results expectedNovember 10, 2026
Study endsNovember 30, 2026
Registry record updatedSeptember 24, 2026
Trial IDNCT07646314 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 25-40 with clinically confirmed piriformis syndrome and moderate to severe pain who can participate in a four-week physiotherapy program.

Probably not a fit

Patients whose pain does not respond to METs or who have exclusionary conditions may not experience benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares two muscle-energy technique approaches for piriformis syndrome. Forty adults with clinically confirmed Piriformis syndrome are randomized to receive either post-isometric relaxation or reciprocal inhibition, in addition to standard conservative care, over four weeks. All participants get cold packs, TENS, ultrasound, stretching, and core/hip strengthening, with the only difference being the 10-minute METs technique. Outcomes include pain, range of motion, and functional disability measured at baseline and after treatment. The study aims to inform physiotherapy practice by identifying which METs approach better complements conventional therapy.

Why it matters

Potential benefit: If successful, the study could identify a more effective manual therapy approach to reduce pain and improve function for piriformis syndrome patients.

How similar studies have gone: Previous work supports METs in musculoskeletal management, but direct comparisons in piriformis syndrome are limited, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Piriformis syndrome clinically confirmed via special tests (e.g., FAIR test, Freiberg sign, Pace test)

* Both gender male and female.
* Age between 25 and 40 years.
* Presence of antalgic gait due to pain.
* Moderate to severe pain (e.g., NPRS score ≥ 4)
* Voluntary consent to participate in the study.
* Medically stable, no acute or unstable medical conditions that would interfere with participation.

Exclusion Criteria:

* Lumber disc herniation or radiculopathy confirmed by imaging or neurological signs

  * History of hip or pelvis surgery.
  * Other neuromuscular or musculoskeletal disorders e.g., stroke, multiple sclerosis, or rheumatoid arthritis
  * Recent lower limb fracture or injury within the last 6 months.
  * Pregnancy due to potential risks and altered biomechanics.
  * Inability to follow instruction
  * Ongoing physiotherapy or alternative treatments

Where it's running

  • Ghurki Hospital Lahore
    Lahore, Punjab Province, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.