Post-ICU Syndrome and Social Factors in Critical Illness Survivors
Official title: Post-ICU Syndrome: Exploring the Role of Social Determinants on Trajectories and Outcomes
Run by Pontificia Universidad Catolica de Chile · NCT07828301 · Data updated 2026-11-12
This study looks at how social factors affect people who survived a critical illness after being on a ventilator for at least 2 days.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Pontificia Universidad Catolica de Chile Academic / other |
| Locations | 5 sites (Quillota and 4 other locations) |
| Status | Recruiting |
| Started | September 15, 2025 |
| Main results expected | March 31, 2029 |
| Study ends | March 31, 2029 |
| Registry record updated | October 1, 2026 |
| Trial ID | NCT07828301 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years and older who have survived critical illness requiring at least 48 hours of mechanical ventilation.
✕Probably not a fit
Patients who do not experience post-ICU symptoms or who are unlikely to participate in follow-up may see limited direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Post-ICU Syndrome (PICS) describes physical, cognitive, and psychological problems that many ICU survivors face after discharge. This observational study aims to explore how social determinants of health influence the development and course of PICS in adults who required mechanical ventilation. Data will be gathered from multiple Chilean centers to describe prevalence, risk factors, and potential associations with quality of life and healthcare utilization. No intervention is specified; the study focuses on observation and characterization of outcomes over time. Findings could help tailor survivorship care and identify groups that may benefit from targeted support.
Why it matters
Potential benefit: If successful, results could guide personalized survivorship care and social support strategies to improve recovery for PICS patients.
How similar studies have gone: Previous research across ICU populations has shown that social determinants of health influence recovery after critical illness, though this observational approach in Chile is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients 18 years of age or older * Patients with critical illness who have been on a ventilator for at least 48 hours Exclusion Criteria: * Presence of mental or intellectual disability before hospitalization * Early limitation of therapeutic effort * Primary neurological injury (e.g., anoxic injury, stroke, or traumatic brain injury) * Anticipated death within 3 months of discharge (e.g., recommended palliative care) * Uncontrolled psychiatric illness at hospital admission * Communication limitations (e.g., does not speak Spanish) * Unlikely to adhere to follow-up (e.g., no fixed address, difficult to locate at follow-up)
Where it's running
-
Clínica San Carlos de Apoquindo
Santiago, Chile Recruiting -
Complejo Asistencial Dr. Sótero del Rio
Santiago, Chile Recruiting -
Hospital Clínico UC Christus
Santiago, Chile Recruiting -
Hospital Biprovincial de Quillota
Quillota, Chile Active not recruiting -
Hospital Las Higueras
Talcahuano, Chile Active not recruiting
Study contacts
- Study coordinator: Paula B Repetto, PhD
- Email: prepetto@uc.cl
- Phone: +56223549024
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Structured telerehabilitation for cardiac patients after ICU care
A remote, four-month cardiac rehabilitation program is being tested to see if it lowers readmissions and deaths and helps physical, cognitive, and emotional recovery after ICU stays for people with post-intensive care syndrome.
-
Virtual reality to help recovery after intensive care (PICS)
This study will try whether immersive virtual-reality brain-training helps adults recovering from ICU-related memory and thinking problems improve more than the same games on a tablet or usual care.
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PROTECT-ICU: Training ICU staff to reduce post-ICU health problems
This trial will test whether training ICU staff to use a standard or expanded care bundle helps adults who spend at least 48 hours in the ICU have fewer physical, thinking, or emotional problems three months after hospital discharge.
-
Wrist-worn activity monitoring to support recovery after intensive care
This project will try a wrist-worn activity monitor to see if it helps clinicians understand recovery for adults discharged from intensive care.
-
Hypnosis to improve well-being after an ICU stay
This trial will test whether short hypnosis sessions given at ICU discharge and again 7 and 14 days later help ICU survivors feel better by day 28.
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Metabolic changes after an ICU stay and long-term physical recovery in ICU survivors
We will test whether metabolic changes during and after an ICU stay help explain long-term physical recovery in adults who needed prolonged ICU care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.