Metabolic changes after an ICU stay and long-term physical recovery in ICU survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational cohort enrolling adult ICU patients who required ventilatory support or had an expected prolonged ICU stay to measure metabolic signatures during critical illness and track physical functioning over time. Researchers will combine clinical data (age, sex, illness severity) with biomarkers of catabolism, muscle metabolism, inflammation, nutrition, and gut health to identify patterns linked to recovery. Participants will undergo serial sampling during and after ICU admission and standardized functional assessments during follow-up visits. The goal is to find potentially modifiable metabolic factors that predict or influence post-intensive care syndrome outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years at time of ICU admission;
* Received ventilatory support (IMV or NIV) within 48 hours after ICU admission with an expected duration of ≥48 hours during ICU stay (irrespective of ICU length of stay); OR
* An expected ICU length of stay of ≥72 hours (irrespective of ventilatory support).

Exclusion Criteria:

* Concurrent participation in an intervention study with an anticipated therapeutic effect on PICS outcomes (physical functioning, cognitive functioning, or mental health status)
* Pre-admission diagnosis of a progressive neurological disease (e.g., Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, progressive forms of multiple sclerosis)
* Participants with neurological paralysis significantly affecting leg function (e.g., spinal cord injury, multiple sclerosis)
* Patients receiving palliative care, with a life expectancy of \<3 months (e.g., hospice care or equivalent)
* Patients who are moribund (i.e., in the final stages of a terminal illness, with imminent death expected)
* Anticipated logistical limitations during recovery phase (e.g., transfer to another hospital, no fixed abode);
* Deemed not suitable to participate based upon the judgement of the treating intensivist.

Where it's running

• Gelderse Vallei Hospital
  Ede, Gelderland, Netherlands Recruiting

Study contacts

• Study coordinator: Arthur HR van Zanten, MD, PhD
• Email: zantena@zgv.nl
• Phone: +31318435964

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.