Polyphenol supplements with resistance and aerobic exercise to improve physical performance in older adults
Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults: A Randomized Controlled Pilot Feasibility Trial
NA · Queen's University · NCT07441343
This project tests whether taking a polyphenol supplement while doing resistance band and cycling exercise helps adults over 60 build strength, recover better, and improve physical function.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Queen's University (other) |
| Locations | 1 site (Kingston, Ontario) |
| Trial ID | NCT07441343 on ClinicalTrials.gov |
What this trial studies
Adults over 60 will take either a polyphenol-rich extract (Phyto-P) or a maltodextrin placebo while participating in supervised resistance band training and stationary cycling. The supplement contains a six-polyphenol blend including chlorogenic acid, chicoric acid, anthocyanins, and quercetin derivatives. Key outcomes include muscle strength, physical performance measures, and inflammatory biomarkers to determine if the supplement enhances exercise adaptations and post-exercise recovery. People with contraindications such as insulin use, anticoagulant therapy, clotting disorders, neuromuscular disease, or conditions limiting exercise participation are excluded.
Who should consider this trial
Good fit: Ideal candidates are non-smoking adults over age 60 who are English-speaking, not on insulin or anticoagulants, and willing to attend supervised exercise sessions in Kingston, Ontario.
Not a fit: People who are highly trained athletes, use insulin, take anticoagulants, have clotting or neuromuscular disorders, or have medical/orthopaedic/psychiatric conditions that limit exercise are unlikely to be eligible or to benefit.
Why it matters
Potential benefit: If successful, the supplement could enhance exercise benefits in older adults by reducing inflammation, improving recovery, and preserving muscle strength and function.
How similar studies have performed: Previous preclinical and human studies of individual polyphenols have shown reductions in inflammatory markers and some improvements in recovery, but combined polyphenol blends paired with exercise are less well tested in older adults.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female or Male * Age \> 60y * Non-Smoking * English Speaking Exclusion Criteria: * Self-reported highly trained individual (training \>3x/week for a specific sport with the goal to compete at a high level) * BMI \< 18.5 * Uses insulin to control blood glucose levels * Any medical, orthopaedic, or psychiatric condition that would be comprise ability to comply with study requirements * Regular user of anti-inflammatory and/or analgesic medication * History of neuromuscular disorder or muscle/bone wasting disease * Determined not ready for exercise by the CSEP GAQ * Use of medication known to affect protein metabolism * Family history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy * Use of anticoagulant medication * Personal or family history of clotting disorder or deep vein thrombosis
Where this trial is running
Kingston, Ontario
- Queen's University School of Kinesiology & Health Studies — Kingston, Ontario, Canada (RECRUITING)
Study contacts
- Study coordinator: Chris McGlory, PhD
- Email: chris.mcglory@queensu.ca
- Phone: 613-533-6000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sarcopenia, Aging, Frailty, Polyphenol, Resistance training, Aerobic exercise, sarcopenia, older adults