Platelet serotonin deficiencies in adults with bleeding problems (Strasbourg)
Official title: Platelet Serotonin Deficiencies: the Strasbourg Experience
Run by University Hospital, Strasbourg, France · NCT07302087 · Data updated 2026-11-12
This project tests whether low serotonin inside platelets is linked to bleeding in adults treated for hemorrhagic syndrome at Strasbourg University Hospital.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | November 25, 2024 |
| Main results expected | February 2026 |
| Study ends | February 2026 |
| Registry record updated | December 24, 2025 |
| Trial ID | NCT07302087 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) treated at Strasbourg University Hospital for a hemorrhagic syndrome suggesting a primary hemostasis abnormality with normal von Willebrand factor between January 1, 2023 and April 1, 2024 are eligible.
✕Probably not a fit
Patients whose bleeding is due to clearly identified non-platelet causes (for example coagulation factor deficiencies or diagnosed von Willebrand disease), those under 18, or those not treated at CHU de Strasbourg are unlikely to benefit from these specific tests.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational series using second-line platelet tests (dense granule nucleotide and intraplatelet serotonin measurements) performed at the Hemorrhagic Disorders Reference Center in Strasbourg. Tests are done when platelet aggregation in platelet-rich plasma suggests a secretion defect or when clinical signs point to a primary hemostasis problem despite normal von Willebrand factor. The cohort includes adult patients managed at CHU de Strasbourg between January 1, 2023 and April 1, 2024 who consent to additional platelet testing. The goal is to document how often intraplatelet serotonin deficiency occurs, whether it is related to medications, and how it correlates with bleeding and platelet function.
Why it matters
Potential benefit: If successful, identifying platelet serotonin deficiencies could help explain unexplained bleeding and guide clinicians to adjust medications or pursue targeted management.
How similar studies have gone: Similar investigations of intraplatelet serotonin are limited and findings are preliminary, so the role of platelet serotonin in bleeding remains incompletely documented.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient (≥ 18 years old) * Treated at Strasbourg University Hospital for a hemorrhagic syndrome, suggesting a primary hemostasis abnormality and normal von Willebrand factor, during the period from January 1, 2023, to April 1, 2024. Exclusion Criteria: \- Refusal to participate in the study
Where it's running
-
Centre de Ressources et de Compétences des Maladies Hémorragiques Constitutionnelles - CHU de Strasbourg - France
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Dominique DESPREZ, MD
- Email: dominique.desprez@chru-strasbourg.fr
- Phone: 33 3 88 12 83 71
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.