Pilot project on treating hypertension during pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CHAP2 pilot project aims to gather preliminary data for a larger multicenter study focused on the treatment of stage 1 hypertension in pregnant women. This study will randomize participants to either a treatment group aiming for blood pressure below 130/80 mmHg or a usual care group, where treatment is only initiated if blood pressure reaches 140/90 mmHg. The primary goal is to assess whether achieving lower blood pressure targets can positively influence birthweight percentiles at delivery. A total of 74 eligible participants will be enrolled in this pilot study at UAB Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Viable singleton gestation
* No fetal anomalies
* Blood pressures 130-139/80-89mmHg on two occasions at least 4 hours apart prior to 20 weeks gestation
* Planning to deliver at UAB Hospital
* No indication for pregnancy termination
* Receiving care at the UAB prenatal clinics

Exclusion Criteria:

* Declines Randomization
* Known diagnosis of chronic hypertension ( BP ≥ 140/90mmHg) or current antihypertensive medication use
* Fetal demise diagnosed prior to enrollment
* Known major structural of chromosomal abnormalities prior to enrollment
* Contraindication to first line antihypertensive (Nifedipine/ Labetalol)
* Comorbidities requiring BP goals \< 130/80mmHg

Where it's running

• UAB
  Birmingham, Alabama, United States Recruiting

Study contacts

• Study coordinator: Donna Dunn, PhD
• Email: dcampbell@uabmc.edu
• Phone: 12058739503

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Telehealth and remote blood pressure management for pregnant women with chronic high blood pressure

  This study tests whether alternating telehealth visits with home blood pressure monitoring and health coaching helps pregnant women (18–45) with chronic high blood pressure compared with standard in-person care.

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• Nifedipine versus enalapril for postpartum high blood pressure

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  Recruiting Phase 4 Nebraska Methodist Health System · Omaha, Nebraska · NCT07023003

• Remote monitoring program for postpartum hypertension in Rhode Island

  This study is testing a new remote monitoring program for postpartum hypertension to see if it helps new moms manage their blood pressure better than the usual self-check methods.

  Recruiting at 3 sites Women and Infants Hospital of Rhode Island · Newport, Rhode Island and 4 other locations · NCT06842875

• Moms@Home: a storytelling mobile app to help manage blood pressure in pregnancy

  This pilot will test whether the Moms@Home mobile app plus a home blood pressure monitor helps pregnant people with gestational or chronic high blood pressure monitor and manage their blood pressure.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06835959

• Using dapagliflozin to reduce cardiovascular risk after hypertensive pregnancies

  This study is testing if the medication dapagliflozin can help reduce heart risks for women who had high blood pressure during pregnancy after they give birth.

  Recruiting Phase 4 University of Michigan · Ann Arbor, Michigan · NCT06785116

• Measuring Blood Pressure in Pregnant Women Using Different Cuffs

  This study is testing if a special forearm cuff gives more accurate blood pressure readings for pregnant women compared to a regular upper arm cuff, especially for those who are very overweight.

  Recruiting Northwestern University · Chicago, Illinois · NCT06466161

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.