Nifedipine versus enalapril for postpartum high blood pressure
Official title: Postpartum Evaluation of Antihypertensives for Control of Hypertension: A Randomized Controlled Equivalence Study
Run by Nebraska Methodist Health System · NCT07023003 · Data updated 2026-11-12
This will see if nifedipine or enalapril better controls high blood pressure in women after giving birth.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 19 Years and up |
| Sex | Women only |
| Enrollment | 850 (estimated) |
| Sponsor | Nebraska Methodist Health System Academic / other |
| Locations | 1 site (Omaha, Nebraska) |
| Status | Recruiting |
| Started | July 11, 2025 |
| Main results expected | July 2028 |
| Study ends | December 2028 |
| Registry record updated | October 22, 2025 |
| Trial ID | NCT07023003 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women admitted for delivery at 24 weeks gestation or later with chronic or pregnancy-related hypertension who speak English and have no contraindications to nifedipine or enalapril are ideal candidates.
✕Probably not a fit
People with absolute contraindications to either drug, persistent heart rate under 60 or over 110, or who do not speak English would not be eligible and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This open-label, randomized phase 4 trial assigns postpartum women with chronic or pregnancy-related hypertension to receive either nifedipine 30 mg XL twice daily or enalapril 10 mg once daily. The study is designed as an equivalence comparison with the primary outcome being hospital readmission for hypertensive complications during the postpartum period. Participants are identified at delivery (≥24 weeks gestation) and must be English-speaking and without contraindications to either medication. The trial is conducted at Methodist Women's Hospital in Omaha, Nebraska.
Why it matters
Potential benefit: If successful, the results could clarify which widely available medication is equally safe and effective for preventing postpartum hypertensive complications and readmissions.
How similar studies have gone: Previous trials have shown nifedipine outperformed labetalol for postpartum hypertension, but enalapril has not been directly compared to nifedipine, so this head-to-head comparison is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. admitted for delivery by cesarean or vaginal delivery 2. 24 weeks gestation or greater 3. Pregnancy related hypertension(HTN) or chronic hypertension. Pregnancy related hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN in patients without CHTN. Exclusion Criteria: 1. Absolute contraindication to either nifedipine or enalapril Relative contraindications will be reviewed with PI. 2. Persistent HR \<60 or \>110 3. Native language other than English
Where it's running
-
Methodist Women's Hospital
Omaha, Nebraska, United States Recruiting
Study contacts
- Principal investigator: Todd Lovgren, MD — Nebraska Methodist Health System
- Study coordinator: Todd Lovgren, MD
- Email: todd.lovgren@nmhs.org
- Phone: 14028151970
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.