Pigmentary glaucoma: does a 120° ab-interno trabeculotomy help

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, retrospective case series of pigmentary glaucoma patients treated with primary, isolated ab-interno 120° trabeculotomy at Zhongnan Hospital. Researchers will collect baseline demographics, eye exams, and prior treatments to describe typical features of pigmentary glaucoma. The primary endpoint is intraocular pressure at six months postoperatively, with secondary observations on medication use, visual field and RNFL stability, and any surgical complications. The goal is to provide clinical evidence to guide individualized surgical decisions for pigmentary glaucoma. The study does not involve a randomized control or prospective design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meet the clinical diagnostic criteria for pigmentary glaucoma, with typical signs of pigment dispersion syndrome, extensive trabecular meshwork pigmentation, pathological intraocular pressure elevation, glaucomatous optic nerve damage, and characteristic visual field defects;
* Underwent primary isolated ab-interno 120° trabeculotomy as the initial surgical treatment;
* Have complete preoperative and postoperative examination data, including slit-lamp biomicroscopy, gonioscopy, intraocular pressure, visual field, and OCT RNFL measurements;
* Able to complete regular follow-up for at least 6 months postoperatively.

Exclusion Criteria:

* Patients with exfoliation syndrome, exfoliative glaucoma, or other types of primary or secondary glaucoma;
* Patients with a history of ocular trauma, intraocular surgery, uveitis, severe retinopathy, or other ocular diseases affecting intraocular pressure and visual function assessment;
* Patients who underwent combined procedures such as concurrent cataract surgery or other anti-glaucoma surgeries during the operation;
* Patients with severe systemic diseases, cognitive or psychiatric disorders that prevent cooperation with examinations and follow-up;
* Patients with missing key clinical or follow-up data that preclude efficacy and prognosis evaluation.

Where it's running

• Zhongnan Hospital of Wuhan University
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: Wen Zeng, doctor — Zhongnan Hospital
• Study coordinator: Min Ke, doctor
• Email: Keminyk@163.com
• Phone: 18672395959

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.