Multi-omics analysis linking zonular laxity and primary angle‑closure glaucoma
Official title: The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Run by Zhongnan Hospital · NCT07539675 · Data updated 2026-11-12
It will test whether molecular differences in eye fluid, blood, and the anterior lens capsule link zonular laxity to primary angle‑closure glaucoma in adults aged 50 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Zhongnan Hospital Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | September 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | April 20, 2026 |
| Trial ID | NCT07539675 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 50 or older with a clinical diagnosis of primary angle‑closure glaucoma who are undergoing glaucoma surgery with intraoperative confirmation of either significant zonular laxity or normal zonular morphology, or age‑ and sex‑matched cataract patients without glaucoma for the control group.
✕Probably not a fit
Patients with secondary glaucoma, prior intraocular surgery, systemic diseases affecting zonules, other severe ocular diseases, or long‑term use of medications that alter connective tissue metabolism are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, multi-omics study comparing PACG patients with intraoperatively confirmed zonular laxity, PACG patients with normal zonules, and age- and sex-matched cataract controls. Researchers will collect aqueous humor, blood, and anterior lens capsule samples during surgery and perform genomic, proteomic, and other molecular analyses. Differentially expressed molecules will be identified and integrated to build potential mechanistic networks explaining how zonular abnormalities may contribute to PACG pathogenesis. No additional experimental interventions are performed beyond standard surgical procedures.
Why it matters
Potential benefit: If successful, the work could reveal molecular mechanisms or biomarkers that help diagnose or guide new treatments for PACG linked to zonular laxity.
How similar studies have gone: Some multi-omics work in glaucoma has identified molecular signatures, but applying multi-omics specifically to zonular laxity in PACG is largely novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinically diagnosed with primary angle-closure glaucoma (PACG) * Aged ≥ 50 years, no gender restriction * Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity * Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology * Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery Exclusion Criteria: * Secondary glaucoma * History of previous intraocular surgery * Systemic diseases that can cause abnormal ocular zonules * Other severe ocular diseases * Long-term use of medications affecting connective tissue metabolism
Where it's running
-
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China Recruiting
Study contacts
- Principal investigator: Xuetian Yu, student — The Second Clinical College of Wuhan University
- Study coordinator: Min Ke, doctor
- Email: Keminyk@163.com
- Phone: 18672395959
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Anterior segment anatomy assessment with swept-source OCT in eye surgery patients
This study tests whether swept-source OCT can detail front-eye anatomy in patients undergoing anterior segment eye surgery.
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Vitreous zonule and its role in primary angle-closure glaucoma.
This project will try 3D ultrasound imaging to see if the vitreous zonule contributes to angle-closure glaucoma in adults with or at risk for primary angle-closure disease and in healthy people.
-
Kahook Dual Blade goniotomy added to cataract surgery for chronic angle-closure glaucoma
This trial will test whether adding Kahook Dual Blade goniotomy to cataract surgery and goniosynechialysis better lowers eye pressure in people aged 40 and older with chronic primary angle-closure glaucoma and cataract.
-
Phacoemulsification with goniosynechialysis versus trabeculectomy for primary angle-closure glaucoma
This trial will see if phacoemulsification plus goniosynechialysis controls eye pressure and causes fewer complications than trabeculectomy in adults with primary angle-closure glaucoma.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.