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Clinical trial Recruiting at 1 site Observational Ages 18 and up Men only

Photon-counting CT to visualize the urethra for prostate cancer radiotherapy planning

Official title: Photon-Counting Computed Tomography-Based Urethral Visualization Without Catheterization for Radiotherapy Planning: A Prospective Pilot Study Under ANTHEM

Run by Istituto Clinico Humanitas · NCT07730203 · Data updated 2026-11-12

This pilot study tests whether photon-counting CT can show the urethra clearly without a catheter in men with prostate cancer who are planning radiotherapy.

Quick facts

Study typeObservational
Ages18 Years and up
SexMen only
Enrollment20 (estimated)
SponsorIstituto Clinico Humanitas
Academic / other
Drugs / interventionsradiation
Locations1 site (Rozzano, Milan)
StatusRecruiting
StartedJune 22, 2026
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJuly 28, 2026
Trial IDNCT07730203 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Men with prostate cancer who are planned for radiotherapy and can undergo urethral catheter placement per their treating institution.

Probably not a fit

Patients with active urinary infection, urethral stricture, recent urethral surgery, or contraindications to catheter placement may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot study explores using photon-counting CT imaging to visualize the urethra during radiotherapy planning for prostate cancer. The goal is to determine if high-detail PCCT images can identify the urethra without requiring a urinary catheter, potentially reducing discomfort and infection risk. Eligible participants are men diagnosed with prostate cancer planned for radiotherapy, with imaging performed as part of planning and catheter use per institutional practice. The study focuses on image acquisition and assessment of urethral visibility in PCCT compared with standard approaches. Results may inform whether PCCT can streamline workflows while preserving accurate organ-at-risk delineation.

Why it matters

Potential benefit: If successful, PCCT could improve urethral visualization during planning without catheter-related discomfort or infection risk.

How similar studies have gone: Previous imaging approaches rely on catheters or MRI for urethral visualization; this PCCT pilot represents a newer approach with limited prior success data in this specific setting.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Prostate cancer candidate to radiotherapy
* Written informed consent.
* Eligibility for urethral catheter placement according to institutional practice

Exclusion Criteria:

* Active or suspected urinary tract infection.
* Known urethral stricture or recent urethral surgery
* Contraindication to catheter placement.

Where it's running

  • IRCCS Humanitas Research Hospital
    Rozzano, Milan, Italy     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Prostate Cancer 1464Istituto Clinico Humanitas 28
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.