PET imaging of NPR-C in healthy adults using 64Cu-NODAGA-CANF (dosimetry)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this early-phase dosimetry study, healthy volunteers receive a single IV dose of 64Cu-NODAGA-CANF and undergo multiple PET-CT scans over 48 hours to map biodistribution and estimate radiation dose. Safety is monitored with vital signs, labs, physical exams, and ECGs, with a telephone follow-up 2–3 days after discharge. The study is conducted at a single center and aims to establish radiotracer safety, distribution, and dosimetry prior to broader use. Eligible participants are adults without cardiovascular disease, including equal representation of sexes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults, 18 years of age or older.
* Healthy adult normal volunteer subjects (4 males and 4 females). "Healthy adult normal volunteer subject" is someone who has volunteered to be imaged and who, based on physical exam and baseline electrocardiogram, has no evidence of cardiovascular disease and is not under the care of a physician for any active medical conditions.

Exclusion Criteria:

* Inability to receive and sign informed consent.
* Patients with an unstable clinical condition that in the opinion of the Sponsor-Investigator or designee precludes participation in the study.
* Inability to tolerate up to 60 minutes in a supine position with arms above head for PET-CT.
* Normal adult volunteer subjects with evidence of disease based on clinical evaluation and/or blood laboratory tests, which are judged by the Sponsor-Investigator or designee to interfere with the objectives of the protocol.
* Prior history of carotid endarterectomy (CEA) or carotid artery stent procedure on the ipsilateral side.
* Past medical history of transient ischemic attack (TIA) or stroke within the last 6 months.
* Unwilling to comply with study procedures and/or unable to be available for the duration of the study outlined in the protocol.
* Claustrophobia or other preventing condition that has previously or would interfere with completion of imaging as outlined in the protocol.
* Participation in another research study with an investigational drug, including a diagnostic or therapeutic radiopharmaceutical, currently or within the last year.
* Currently pregnant or lactating. All female subjects of childbearing potential must have a documented negative pregnancy test (serum or urine hCG) performed within 24 hours immediately prior to the administration of 64Cu-NODAGA-CANF or documented post-menopausal defined as the cessation of menses for ≥ 12 months or documentation of having a bilateral oophorectomy and/or hysterectomy.

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Study coordinator: Molly Mohrman
• Email: mohrmanm@wustl.edu
• Phone: 314-747-4633

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Oura Ring validation for sleep using gold-standard sleep tests

  This study tests how well the Oura Ring matches the gold-standard sleep test ( PSG ) in healthy adults and people with sleep apnea.

  Recruiting Ouraring Inc. · St Louis, Missouri · NCT07908199

• Magnetic field maps with NV sensors for non-invasive heart measurements

  This study tests whether diamond-based NV magnetometers can non-invasively detect and map the heart's magnetic field in healthy adults.

  Recruiting Robert Bosch GmbH · Renningen · NCT07908173

• Cognitive Tasks and Models in a Large Online Sample

  This study tests cognitive tasks and computational models in a large online group to see if these tools can help predict symptoms like hallucinations and delusions in the general population.

  Recruiting at 2 sites Washington University School of Medicine · Minneapolis, Minnesota and 1 other locations · NCT07900893

• Single-dose study of DTI-117 given by injection in healthy adults

  Researchers are testing a one-time dose of DTI-117 in healthy adult volunteers to see if it is safe and how it moves through the body.

  Recruiting Phase 1 Dignify Therapeutics · Austin, Texas · NCT07882472

• Data-driven rural wellness interventions for vitality and endurance (DRIVE) pilot

  This pilot test will see if personalized wellness coaching based on genomic, clinical, behavioral, and functional data can be feasibly delivered in a rural setting and improve cardiometabolic, cognitive, mental health, and functional outcomes over four months.

  Recruiting McLaughlin Research Institute for Biomedical Sciences, Inc. · Great Falls, Montana · NCT07872995

• White potato meals and when you eat them: how timing changes blood sugar and appetite

  This study tests how eating white potatoes with meals at different times affects blood sugar, hunger, and how much people eat later in healthy adults.

  Recruiting Toronto Metropolitan University · Toronto, Ontario · NCT07854938

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.