Personalized VT ablation using high-precision heart mapping
Official title: Treatment Based on High Precision Cardiac Mapping: Advancing Personalized Outcomes Through Optimized Localization
Run by Hospital Clinic of Barcelona · NCT07746336 · Data updated 2026-11-12
This study tests a combined non-invasive and invasive heart-mapping approach to guide VT ablation in adults with structural heart disease and prior VT or ICD therapies.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Hospital Clinic of Barcelona Academic / other |
| Locations | 1 site (Barcelona) |
| Status | Recruiting |
| Started | July 15, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | August 25, 2026 |
| Trial ID | NCT07746336 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with structural heart disease and documented sustained VT or recurrent ICD therapies who are eligible for VT ablation and can complete ECG imaging requirements.
✕Probably not a fit
Patients without VT substrates suitable for the mapping approach or unable to tolerate the imaging or catheter procedures may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
APOLO-VT investigates whether a multimodal mapping workflow, using Volumetric ECG imaging alongside invasive electroanatomical mapping, can safely and effectively guide ventricular tachycardia ablation. The trial will assess feasibility, safety, and potential clinical impact in adults with ischemic or non-ischemic cardiomyopathy who are scheduled for VT ablation. Participants will undergo the integrated mapping process with the ACORYS system to target VT substrates more precisely. The study is conducted at a single leading center and aims to improve ablation outcomes and reduce VT recurrences. Outcomes will inform future refinement of patient-specific ablation strategies.
Why it matters
Potential benefit: If successful, patients may experience more precise ablation of VT substrates, potentially reducing VT episodes and ICD therapies.
How similar studies have gone: Early studies in multimodal mapping have shown promise in improving ablation targeting, though this specific integrated approach is novel in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria * Age ≥18 years. * Diagnosis of structural heart disease (ischemic or non-ischemic cardiomyopathy). * Documented sustained monomorphic VT (clinical or inducible), or recurrent ICD therapies for VT. * Scheduled for catheter ablation of VT according to current international guidelines. * Ability to provide written informed consent. * Ability to remain upright or seated to allow a video for 3D torso reconstruction for ECGi acquisition. Exclusion criteria * Age \<18 years. * Pregnant or breastfeeding women. * Inability to provide informed consent due to physical or mental condition. * Contraindication to computed tomography or cardiac magnetic resonance (magnetic resonance imaging-incompatible devices, claustrophobia). * Contraindication to contrast agents (gadolinium allergy or severe renal dysfunction with estimated glomerular filtration rate \<30 mL/min/1.73 m²). * Inability to remain upright for torso 3D reconstruction required for ECGi. * Life expectancy \<1 year due to non-cardiac comorbidity.
Where it's running
-
Hospital Clinic, University of Barcelona
Barcelona, Spain Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.