Personalized pain management after lumbar spine surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on improving postoperative pain management for adults undergoing lumbar spinal fusion and decompression surgery by evaluating the effects of genetic factors on the efficacy and safety of commonly used opioids, oxycodone and methadone. It aims to identify how multiple genes interact to influence pain perception and opioid responses, which could lead to more personalized and effective pain management strategies. The study addresses the high incidence of uncontrolled pain and opioid-related adverse effects in this patient population, aiming to reduce the risks associated with opioid use. By understanding these genetic influences, the research seeks to optimize opioid dosing and minimize complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \>18 years of age
* American Society of Anesthesiologists (ASA) Physical Status 1, 2, or 3
* Undergoing lumbar spine surgeries (lumbar spine decompression, multilevel posterior spine fusion, internal fixation or a combination) for degenerative lumbar spine and lumbar spinal stenosis and requiring opioids for perioperative pain management

Exclusion Criteria:

* Children (\<18 years of age)
* Pregnant women
* American Society of Anesthesiologists (ASA) Physical Status 4 or above
* Non-English speaking
* Outpatient surgery
* Concomitant additional surgical procedures
* Significant liver or kidney dysfunction
* Significant cardiorespiratory compromise
* Patients with polysubstance use (e.g., cocaine, marijuana, amphetamine, etc.)

Where it's running

• UPMC Montefiore Hospital
  Pittsburgh, Pennsylvania, United States Recruiting
• UPMC Presbyterian Hospital
  Pittsburgh, Pennsylvania, United States Recruiting
• UPMC Pain Medicine at Centre Commons
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Kathirvel Subramaniam, MD, MPH — University of Pittsburgh
• Study coordinator: Amy Monroe, MPH, MBA
• Email: monroeal@upmc.edu
• Phone: 412-623-6382

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating LDGraft for lumbar spine surgery

  This study is testing a new device called LDGraft to see if it is safe and effective for patients having surgery for lower back problems compared to using human tissue.

  Recruiting at 4 sites Phase 1/2 Locate Bio Ltd · Fort Wayne, Indiana and 3 other locations · NCT06462729

• Evaluating the impact of zolpidem on recovery after lumbar spine fusion surgery

  This study is testing if giving a sleep aid called zolpidem to patients having spine surgery can help them recover better and feel less pain.

  Recruiting Phase 4 University of Southern California · Los Angeles, California · NCT05746143

• Evaluating text messages versus handouts for lumbar spine surgery recovery

  This study is testing whether sending daily text messages or giving out handouts helps adults recover better after lumbar spine surgery by reducing hospital readmissions and improving their pain and anxiety levels.

  Recruiting Duke University · Durham, North Carolina · NCT04140344

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.