Personalized pacing rate to see if higher lower rate helps heart and brain flow
Official title: Impact of Allometric Pacing Rate on Ventricular Diastolic Function and Cerebral Blood Flow in Hypertensive Patients With Sinus Node Dysfunction
Run by Medtronic Cardiac Rhythm and Heart Failure · NCT07589452 · Data updated 2026-11-12
In hypertensive patients with bradycardia who need a dual-chamber pacemaker, the study tests whether setting a higher, personalized pacing rate improves heart function and brain blood flow compared with the standard 60 bpm.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Medtronic Cardiac Rhythm and Heart Failure Industry-sponsored |
| Locations | 1 site (Taiyuan, Shanxi) |
| Status | Recruiting |
| Started | May 14, 2026 |
| Main results expected | January 31, 2028 |
| Study ends | May 31, 2028 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT07589452 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 65 and older with hypertension and planned dual-chamber pacemaker implantation, and a resting or average heart rate at or below 60 bpm.
✕Probably not a fit
Patients without blood pressure or diastolic function issues related to pacing, or with contraindications to higher pacing rates, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares two pacing strategies in older adults with bradycardia and hypertension who are receiving a dual-chamber pacemaker. Participants are assigned 1:1 to either the standard pacing rate of 60 bpm or a personalized higher rate of 75 bpm, based on height or clinical assessment. Baseline and 3-month follow-up assessments include blood pressure, cardiac function, and cerebral blood flow measurements. The study aims to determine whether a higher programmed lower rate improves diastolic function and cerebral perfusion without increasing risk. Results will inform whether a personalized pacing approach offers a clinical advantage in this population.
Why it matters
Potential benefit: If successful, patients may experience better heart relaxation and improved brain blood flow through a tailored pacing rate.
How similar studies have gone: Previous pulse-rate personalization approaches have shown potential in related pacing contexts, but this exact allometric-rate strategy in this population is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥65 years of age * Planned implantation of a dual chamber pacemaker with physiological pacing * Resting sinus heart rate ≤60 bpm, or average 24 hour Holter heart rate ≤60 bpm * Documented history of hypertension or office systolic blood pressure ≥130 mmHg Exclusion Criteria: * Diagnosis of secondary hypertension * Diagnosis of or possible concomitant heart failure, with ejection fraction ≤50% * Paroxysmal, persistent, or permanent atrial fibrillation * Status post CABG or PCI * Structural heart disease * Risk of ventricular tachyarrhythmia * Severe hepatic or renal dysfunction * Active acute infection * Inability to sign informed consent * Pregnancy or planned pregnancy during the study period * Enrollment in other clinical studies that may affect the objectives of this study
Where it's running
-
Shanxi Cardiovascular Hospital
Taiyuan, Shanxi, China Recruiting
Study contacts
- Study coordinator: Georgiana Zou
- Email: georgiana.zou@medtronic.com
- Phone: +86 18918711140
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.