Personalized goal-based rehabilitation during pediatric stem cell transplant
Official title: Using Goal Attainment Scale (GAS) to Increase Active Involvement of Patients and Their Family in the Identification of Functional Objectives During Hospitalization for Hematopoietic Stem Cell Transplantation (HSCT): a Randomized Controlled Trial.
Run by Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna · NCT07372690 · Data updated 2026-11-12
This will try a personalized Goal Attainment Scale to help children and teens (6 months–17 years) keep or improve physical abilities during hematopoietic stem cell transplantation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Months to 17 Years |
| Sex | All |
| Enrollment | 176 (estimated) |
| Sponsor | Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna Academic / other |
| Locations | 1 site (Torino, TO) |
| Status | Recruiting |
| Started | June 23, 2022 |
| Main results expected | June 23, 2027 |
| Study ends | December 23, 2027 |
| Registry record updated | January 28, 2026 |
| Trial ID | NCT07372690 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children and adolescents aged 6 months to 17 years 11 months undergoing hematopoietic stem cell transplantation for oncologic or hematologic conditions who are not already receiving specific rehabilitation and whose guardians provide consent.
✕Probably not a fit
Patients who cannot comply with study visits or procedures, those already receiving targeted rehabilitation at enrollment, or those with medical complications that prevent participation in exercise may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this single-center randomized controlled trial, children and adolescents undergoing hematopoietic stem cell transplantation are assigned to a Goal Attainment Scale (GAS)–guided rehabilitation program or a control intervention. The experimental group receives individualized goal-setting with GAS plus an exercise and rehabilitation program, while the control group receives standard rehabilitation counselling and exercise as per usual care. Outcomes include GAS-defined goal achievement, parent and adolescent perceptions of functional change from admission through follow-up, feasibility measures, and objective motor-performance metrics. The study is conducted at a pediatric transplant center in Torino, Italy and enrolls patients aged 6 months to 17 years 11 months with oncologic or hematologic indications for HSCT.
Why it matters
Potential benefit: If successful, GAS-guided rehabilitation could help preserve or improve motor function and quality of life for children undergoing HSCT.
How similar studies have gone: Previous research and meta-analyses show exercise and rehabilitation are safe and can prevent decline in physical performance and quality of life in pediatric HSCT, but use of GAS for goal-directed rehab in this population is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 6 months - 17 years and 11 months * diagnosis of oncological or hematological disease undergoing HSCT * No specific rehabilitation treatment ongoing at the moment of recruitment * Written informed consent from patient or parents/legal representative, and age-appropriate assent. Exclusion Criteria: * Patients that are not able and willing to comply with study visits and procedures.
Where it's running
-
A.O.U. Città della Salute e della Scienza - OIRM
Torino, To, Italy Recruiting
Study contacts
- Principal investigator: Francesco Saglio, PhD Medical Doctor — A.O.U. Città della Salute e della Scienza - OIRM
- Study coordinator: Francesco Saglio, PhD Medical Doctor
- Email: francesco.saglio@unito.it
- Phone: +39 0113135449
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.